2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. ACTH (4-11)

ACTH (4-11)  (Synonyms: Adrenocorticotropic Hormone (4-11), human)

目录号: HY-P1503 纯度: 98.48%
Data Sheet SDS COA 产品使用指南 技术支持

实验小贴士

ACTH (4-11) 是一种促肾上腺皮质激素片段，仅在高浓度 (100 和 1000 nM) 时才具有弱的 α-黑素细胞刺激激素 (α-MSH) 效力。

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Custom Peptide Synthesis

ACTH (4-11) Chemical Structure

ACTH (4-11) Chemical Structure

CAS No. : 67224-41-3

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规格 价格 是否有货 数量
1 mg ￥500
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5 mg ￥1300
In-stock
10 mg ￥2100
In-stock
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100 mg   询价  

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ACTH (4-11) 相关抗体

Top Publications Citing Use of Products

查看 Melanocortin Receptor 亚型特异性产品:

查看所有亚型
MC1R MC3R MC2R MC4R MC5R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).

体外研究
(In Vitro)

α-melanocyte stimulating hormone (MSH) induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. Adrenocorticotropic hormone (ACTH) possesses the same amino acid sequence as MSH does. α-MSH induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. ACTH (4-11) loses almost all activity for the binding to melanocortin receptor 1 (MC1R)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ACTH (4-11) 相关抗体:
分子量

1090.26

Formula

C50H71N15O11S
CAS 号
性状

固体

颜色

White to off-white

Sequence

Met-Glu-His-Phe-Arg-Trp-Gly-Lys
Sequence Shortening

MEHFRWGK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

ACTH (4-11) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • 储存条件中写的 under nitrogen 是什么意思呢？这个是要放在液氮吗？如果我放在 -80 ℃ 是不是不需要 under nitrogen 呢？

    under nitrogen 是要充氮气保存的意思，如果化合物容易被氧化，长期储存是建议在惰性气体（例如氮气）中储存，避免长时间接触空气。产品储存在 -80 ℃ 也是需要充氮气储存的。氮气的置换操作可以关注我们微信公众号“MCE 抑制剂”输入“氮气”，会有相关的操作指南。

Keywords:

ACTH (4-11)67224-41-3Adrenocorticotropic Hormone (4-11), humanMelanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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