AMG-009

目录号: HY-19499 纯度: 98.08%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

AMG-009 是 prostaglandin D2 的有效拮抗剂，对 CRTH2 和 DP 受体的 IC₅₀ 值分别为 3 nM 和 12 nM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

AMG-009 Chemical Structure

CAS No. : 1027847-67-1

1. 客户无需承担相应的运输费用。

2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥1727	In-stock
5 mg	￥1350	In-stock
10 mg	￥2160	In-stock
25 mg	￥4230	In-stock
50 mg	现货	询价
100 mg	现货	询价
200 mg		询价
500 mg		询价

or 大包装询价

* Please select Quantity before adding items.

AMG-009 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型

DP EP FP IP TXA₂/TP TXB₂

生物活性
纯度 & 产品资料
参考文献

生物活性

AMG-009 is a potent antagonist of prostaglandin D2, with IC₅₀ of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.

IC₅₀ & Target^[3]

3 nM (IC₅₀)

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.003 μM Compound: AMG-009	Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSA Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSA	[PMID: 22119474]
HEK293	IC₅₀	0.003 μM Compound: 31, AMG-009	Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK 293 cells in presence of 0.5% BSA by scintillation counting Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK 293 cells in presence of 0.5% BSA by scintillation counting	[PMID: 19804971]
HEK293	IC₅₀	0.003 μM Compound: 1, AMG-009	Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin	[PMID: 24900313]
HEK293	IC₅₀	0.012 μM Compound: AMG-009	Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSA Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 0.5 % BSA	[PMID: 22119474]
HEK293	IC₅₀	0.012 μM Compound: 31, AMG-009	Displacement of [3H]-PGD2 from human DP receptor expressed in HEK 293 cells in presence of 0.5% BSA by scintillation counting Displacement of [3H]-PGD2 from human DP receptor expressed in HEK 293 cells in presence of 0.5% BSA by scintillation counting	[PMID: 19804971]
HEK293	IC₅₀	0.012 μM Compound: 1, AMG-009	Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin	[PMID: 24900313]
HEK293	IC₅₀	0.021 μM Compound: AMG-009	Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 50% plasma Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 50% plasma	[PMID: 22264478]
HEK293	IC₅₀	0.021 μM Compound: AMG-009	Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasma Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasma	[PMID: 22119474]
HEK293	IC₅₀	0.021 μM Compound: 1, AMG-009	Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma	[PMID: 24900313]
HEK293	IC₅₀	0.28 μM Compound: AMG-009	Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 50% plasma Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 50% plasma	[PMID: 22264478]
HEK293	IC₅₀	0.28 μM Compound: AMG-009	Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasma Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasma	[PMID: 22119474]
HEK293	IC₅₀	0.28 μM Compound: 1, AMG-009	Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma	[PMID: 24900313]
HEK293	IC₅₀	12 nM Compound: AMG 009	Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting	[PMID: 24825301]
HEK293	IC₅₀	3 nM Compound: AMG 009	Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting	[PMID: 24825301]

体外研究
(In Vitro)

AMG-009 inhibits PGD2-induced down-modulation of CRTH2 on CD16 negative granulocytes (eosinophils) in human whole blood with a K_i of 1 nM. AMG 009 also inhibits PGD2-induced cAMP response mediated by DP in platelets in 80% human whole blood with a K_i of 148 nM. AMG 009 inhibits guinea pig CRTH2 receptors (IC₅₀=3 nM) and a PGD2-induced cAMP response assay with cells expressing the guinea pig DP receptors (K_i=131 nM)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

AMG 009 (3, 10 or 30 mg/kg, s.c.) results in a dose dependent decrease in airway resistance provoked by PGD2 aerosol in an acute guinea pig model^[1]. In a guinea pig model of PGD2-induced airway constriction, AMG 009 significantly improves DP potency, with K_b of 82 nM^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

581.46

Formula

C₂₆H₂₆Cl₂N₂O₇S

CAS 号

1027847-67-1

性状

固体

颜色

White to light brown

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 125 mg/mL (214.98 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7198 mL	8.5990 mL	17.1981 mL
5 mM	0.3440 mL	1.7198 mL	3.4396 mL
10 mM	0.1720 mL	0.8599 mL	1.7198 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.08%

选择批次：

Data Sheet (597 KB) SDS (251 KB)

COA (195 KB) HNMR (299 KB) LCMS (94 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Liu J, et al. Discovery and optimization of CRTH2 and DP dual antagonists. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6419-23. [Content Brief]

[2]. Liu J, et al. Discovery of AMG 853, a CRTH2 and DP Dual Antagonist. ACS Med Chem Lett. 2011 Mar 2;2(5):326-30. [Content Brief]

[3]. Johnson MG, et al. Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2877-80. [Content Brief]

AMG-009 相关分类

Inflammation/Immunology Endocrinology

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7198 mL	8.5990 mL	17.1981 mL	42.9952 mL
	5 mM	0.3440 mL	1.7198 mL	3.4396 mL	8.5990 mL
	10 mM	0.1720 mL	0.8599 mL	1.7198 mL	4.2995 mL
	15 mM	0.1147 mL	0.5733 mL	1.1465 mL	2.8663 mL
	20 mM	0.0860 mL	0.4300 mL	0.8599 mL	2.1498 mL
	25 mM	0.0688 mL	0.3440 mL	0.6879 mL	1.7198 mL
	30 mM	0.0573 mL	0.2866 mL	0.5733 mL	1.4332 mL
	40 mM	0.0430 mL	0.2150 mL	0.4300 mL	1.0749 mL
	50 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8599 mL
	60 mM	0.0287 mL	0.1433 mL	0.2866 mL	0.7166 mL
	80 mM	0.0215 mL	0.1075 mL	0.2150 mL	0.5374 mL
	100 mM	0.0172 mL	0.0860 mL	0.1720 mL	0.4300 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-0091027847-67-1AMG009AMG 009Prostaglandin ReceptorInhibitorinhibitorinhibit

您最近查看的产品:

产品名称：

* 需求量：

* 客户姓名：

* Email：

* 电话：

* 公司或机构名称：

留言给我们：

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AMG-009