2. Anti-infection
  3. Parasite
  4. AN11251

AN11251 是一种有效的、具有口服活性的抗Wolbachia 的活性分子，有潜力用于盘尾丝虫病和淋巴丝虫病的相关研究，其对感染 Wolbachia 的LDW1 和C6/36 细胞的EC50 值分别为 1.5 nM 和 15 nM。

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AN11251 Chemical Structure

AN11251 Chemical Structure

CAS No. : 2130750-59-1

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规格 是否有货
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100 mg   询价  
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AN11251 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines[1].

体内研究
(In Vivo)

AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae[1].
Dosage: 25 mg/kg.
Administration: Orally, BID for 7 or 14 days.
Result: Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively.
分子量

528.42

Formula

C29H38BFO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AN11251 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AN112512130750-59-1AN 11251AN-11251ParasiteInhibitorinhibitorinhibit

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目录号：
HY-111543
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