2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Biricodar

Biricodar  (Synonyms: 比立考达; VX-710)

目录号: HY-13574A 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

Biricodar (VX-710) 是 P-glycoprotein 和 MRP-1 的调节剂; 在多药耐药细胞中显示出有效的化学敏化活性。

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Biricodar Chemical Structure

Biricodar Chemical Structure

CAS No. : 159997-94-1

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规格 价格 是否有货 数量
1 mg ￥4000
In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Biricodar:

Biricodar 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

体外研究
(In Vitro)

Biricodar shows activity against both P-glycoprotein (Pgp) and MRP-1 and also has activity in increasing drug uptake and retention and reversing drug resistance mediated by wild-type BCRP (BCRPR482). In 8226/Dox6 cells (Pgp), biricodar increases mitoxantrone and daunorubicin uptake by 55 and 100%, respectively, increases their retention by 100 and 60%, respectively, and increases their cytotoxicity 3.1- and 6.9-fold, respectively. Biricodar also increases the uptake, retention and cytotoxicity in HL60/Adr (MRP-1) and 8226/MR20 cells (BCRP(R482)), but has little effect in MCF7 AdVP3000 cells (BCRP(R482T))[1]. VX-710 is a non-macrocyclic pipecolinate derivative which binds the FK506 receptor protein. VX-710 has been shown to restore sensitivity in a range of multidrug-resistant cells, including myeloma, melanoma, carcinoma and leukaemia[2]. Biricodar effectively inhibits photoaffinity labeling of P-glycoprotein by [3H]azidopine or [125I]iodoaryl azido-prazosin with EC50 values of 0.75 and 0.55 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biricodar 相关抗体:
Clinical Trial
分子量

603.71

Formula

C34H41N3O7
CAS 号
性状

油状物

颜色

Colorless to light yellow

中文名称

比立考达
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (165.64 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6564 mL 8.2821 mL 16.5642 mL
5 mM 0.3313 mL 1.6564 mL 3.3128 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB) HNMR (314 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

To study cytotoxicity in suspension cell lines, cells are plated in 96-well tissue culture plates at a density of 10,000 cells/well in RPMI 1640 supplemented with 10% FCS, 2 mM l-glutamine, 20 units/mL penicillin, and 20 μg/mL streptomycin. Drug is added to the culture medium to achieve final concentrations of 0.3 nM to 10 μM, with half-log increments, with and without biricodar at a final concentration of 2.5 μM. The final volume of medium per well is 100 μL. Cells are incubated for 96 h at 37°C in a fully humidified atmosphere of 5% CO2 in air. Cell growth is assessed by the WST-1 colorimetric assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Biricodar 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6564 mL 8.2821 mL 16.5642 mL 41.4106 mL
5 mM 0.3313 mL 1.6564 mL 3.3128 mL 8.2821 mL
10 mM 0.1656 mL 0.8282 mL 1.6564 mL 4.1411 mL
15 mM 0.1104 mL 0.5521 mL 1.1043 mL 2.7607 mL
20 mM 0.0828 mL 0.4141 mL 0.8282 mL 2.0705 mL
25 mM 0.0663 mL 0.3313 mL 0.6626 mL 1.6564 mL
30 mM 0.0552 mL 0.2761 mL 0.5521 mL 1.3804 mL
40 mM 0.0414 mL 0.2071 mL 0.4141 mL 1.0353 mL
50 mM 0.0331 mL 0.1656 mL 0.3313 mL 0.8282 mL
60 mM 0.0276 mL 0.1380 mL 0.2761 mL 0.6902 mL
80 mM 0.0207 mL 0.1035 mL 0.2071 mL 0.5176 mL
100 mM 0.0166 mL 0.0828 mL 0.1656 mL 0.4141 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biricodar159997-94-1VX-710比立考达VX710VX 710P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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