2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. ADC Cytotoxin Microtubule/Tubulin
  4. MMAD-d8

MMAD-d8  (Synonyms: Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8)

目录号: HY-15581S 纯度: 98.95%
COA 产品使用指南

摩尔计算器

MMAD-d8D是MMAD的氘代形式。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MMAD-d<sub>8</sub> Chemical Structure

MMAD-d8 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥8800
In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of MMAD-d8:

MMAD-d8 相关抗体

Top Publications Citing Use of Products

查看 ADC Cytotoxin 亚型特异性产品:

查看所有亚型
Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.

IC50 & Target

Auristatin

 

体外研究
(In Vitro)

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MMAD-d8 相关抗体:
体内研究
(In Vivo)

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

779.11

Formula

C41H58D8N6O6S
非标记 CAS

203849-91-6
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (128.35 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2835 mL 6.4176 mL 12.8352 mL
5 mM 0.2567 mL 1.2835 mL 2.5670 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MMAD-d8 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2835 mL 6.4176 mL 12.8352 mL 32.0879 mL
5 mM 0.2567 mL 1.2835 mL 2.5670 mL 6.4176 mL
10 mM 0.1284 mL 0.6418 mL 1.2835 mL 3.2088 mL
15 mM 0.0856 mL 0.4278 mL 0.8557 mL 2.1392 mL
20 mM 0.0642 mL 0.3209 mL 0.6418 mL 1.6044 mL
25 mM 0.0513 mL 0.2567 mL 0.5134 mL 1.2835 mL
30 mM 0.0428 mL 0.2139 mL 0.4278 mL 1.0696 mL
40 mM 0.0321 mL 0.1604 mL 0.3209 mL 0.8022 mL
50 mM 0.0257 mL 0.1284 mL 0.2567 mL 0.6418 mL
60 mM 0.0214 mL 0.1070 mL 0.2139 mL 0.5348 mL
80 mM 0.0160 mL 0.0802 mL 0.1604 mL 0.4011 mL
100 mM 0.0128 mL 0.0642 mL 0.1284 mL 0.3209 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMAD-d8Demethyldolastatin 10-d8Monomethylauristatin D-d8Monomethyl Dolastatin 10-d8ADC CytotoxinMicrotubule/TubulinADC PayloadInhibitorinhibitorinhibit

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目录号：
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