2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. Glucokinase activator 1

Glucokinase activator 1 是针对肝脏的葡萄糖激酶活化剂，EC50 为34 nM。

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Glucokinase activator 1 Chemical Structure

Glucokinase activator 1 Chemical Structure

CAS No. : 1328987-85-4

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Glucokinase activator 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.

IC50 & Target

EC50: 34 nM (Glucokinase)[1]
体内研究
(In Vivo)

Glucokinase activator 1 (3 to 300 mg/kg, oral, 180 minutes) shows a dose dependent improvement in glucose excursion in oGTT in a DIO mouse model of T2D. The predominant liver-directed tissue distribution of Glucokinase activator 1 ensures a good safety window with respect to hypoglycemia over a 10-fold dose range[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (age 8-10 weeks; 25±5 g)[1]
Dosage: 1 or 3 mg/kg (i.v.), 30 mg/kg (oral)
Administration: I.v. or oral
Result: Showed an excellent PK profile and exhibited 35- and 68- fold higher liver concentrations at 1 and 3 h time point, respectively, compared with plasma[1].
Animal Model: Male C57BL/6J mice of 10-12 weeks[1]
Dosage: 3 to 300 mg/kg
Administration: Oral (15, 30, 60, 120 and 180 minutes)
Result: Demonstrated 21% and 34% significant AUC glucose reduction at oral dose of 30 and 100 mg/kg, respectively[1].
分子量

586.58

Formula

C27H20F2N2O7S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glucokinase activator 1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucokinase activator 11328987-85-4Glucokinase activator1Glucokinase activator-1GlucokinaseHexokinase IVHexokinase DInhibitorinhibitorinhibit

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目录号：
HY-101788
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