1. Metabolic Enzyme/Protease Anti-infection
  2. HIV Integrase HIV
  3. HIV-1 integrase inhibitor 3

HIV-1 integrase inhibitor 3 是一种 HIV-1 整合酶链转移 (INST) 抑制剂,其 IC50 值为 2.7 nM。

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HIV-1 integrase inhibitor 3 Chemical Structure

HIV-1 integrase inhibitor 3 Chemical Structure

CAS No. : 1638504-56-9

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生物活性

HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.

IC50 & Target

IC50: 2.7 nM (INST)[1]

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HOS CC50
> 250 μM
Compound: 6'b
Cytotoxicity against HOS cells assessed as reduction in cell viability after 48 hrs by ATPLite luminescence assay
Cytotoxicity against HOS cells assessed as reduction in cell viability after 48 hrs by ATPLite luminescence assay
[PMID: 28737946]
体外研究
(In Vitro)

HIV-1 integrase inhibitor 3 (compound 4c) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM. HIV-1 integrase inhibitor 3 also displays an antiviral inhibitory potency against the Q148H/G140S mutant with an EC50 of 7 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

432.42

Formula

C21H22F2N4O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

HIV-1 integrase inhibitor 3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
HIV-1 integrase inhibitor 3
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HY-108817
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