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  4. Hydroxystilbamidine bis(methanesulfonate)

Hydroxystilbamidine bis(methanesulfonate) 

目录号: HY-108166A 纯度: 97.01%
COA 产品使用指南

摩尔计算器

Hydroxystilbamidine bis(methanesulfonate) 是一种能够结合 DNA 和 RNA 的染料，是一种荧光阳离子染料，常用作逆行神经元示踪剂， 也被发现是细胞核糖核酸酶的强效抑制剂。

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Hydroxystilbamidine bis(methanesulfonate) Chemical Structure

Hydroxystilbamidine bis(methanesulfonate) Chemical Structure

CAS No. : 223769-64-0

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规格 价格 是否有货 数量
1 mg ￥850
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Other Forms of Hydroxystilbamidine bis(methanesulfonate):

Hydroxystilbamidine bis(methanesulfonate) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hydroxystilbamidine bis(methanesulfonate) is a dye that can bind to DNA and RNA; it's a fluorescent cationic dye, often used as a retrograde neuronal tracer and has also been found to be a potent inhibitor of cellular ribonucleases.

体外研究
(In Vitro)

It is found that the trypanocidal dye Hydroxystilbamidine bis(methanesulfonate) permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes. The heparin gradient shows some polyribosomes, whereas the Hydroxystilbamidine bis(methanesulfonate) gradient shows a remarkably large peak of very heavy polyribosomes. This peak is obtained reproducibly if Hydroxystilbamidine bis(methanesulfonate) is present before the addition of NP-40[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hydroxystilbamidine bis(methanesulfonate) 相关抗体:
体内研究
(In Vivo)

Hydroxystilbamidine bis(methanesulfonate) is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine bis(methanesulfonate) depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine bis(methanesulfonate)-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine bis(methanesulfonate) treated mice and the control group is essentially at the background level[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

472.54

Formula

C18H24N4O7S2
CAS 号
性状

固体

颜色

Light yellow to yellow

Emission (Em)

625
Excitation (Ex)

360
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (105.81 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 50 mg/mL (105.81 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1162 mL 10.5811 mL 21.1622 mL
5 mM 0.4232 mL 2.1162 mL 4.2324 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 97.01%

COA (290 KB) HNMR (288 KB) LCMS (87 KB)

产品使用指南 (1538 KB)
参考文献
Kinase Assay
[1]

Silkwork larvae are used in this study. Larvae on the fourth or fifth day of the fifth instar (~4.2 g body weight) are injected with 35 μL of a solution of 10 mg/mL cyclobeximidein H2O. After 5 min, the animals are immobilized in ice, and posterior silk glands are dissected and washed in ice-cold 0.15 M NaCl, 0.015 M Na citrate, 100 μg/mL cycloheximide. Washed glands from two larvae are placed in a homogenizer containing 4.7 mL of 40 mM triethanolamine-HCl, pH 7.5, 0.15 M sucrose, 0.1 M KCI, 3 mM MgCl2, 2 mM reduced glutathione, 10 μg/mL cycloheximide, 750 μg/mL Escherichia coli tRNA, and an appropriate concentration of RNase inhibitor (sodium heparin, 1.5 μg/mL or Hydroxystilbamidine bis(methanesulfonate), 1.5 mM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Mice (six per group) are given various doses of Hydroxystilbamidine bis(methanesulfonate) (HSB) 3, 2, and 1 day before antigen. Other groups are given Hydroxystilbamidine bis(methanesulfonate) 1 or 2 days after the injection of antigen. Another group of mice receive antigen and Hydroxystilbamidine bis(methanesulfonate) simultaneously. A control group receives only antigen. The antigen dose consists of 2×108 sheep erythrocytes (SRBC). Four days after the injection of SRBC, the mice are sacrificed and spleens are removed and assayed for plaque-forming cell (PFC) by the plaque assay[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Hydroxystilbamidine bis(methanesulfonate) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.1162 mL 10.5811 mL 21.1622 mL 52.9056 mL
5 mM 0.4232 mL 2.1162 mL 4.2324 mL 10.5811 mL
10 mM 0.2116 mL 1.0581 mL 2.1162 mL 5.2906 mL
15 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5270 mL
20 mM 0.1058 mL 0.5291 mL 1.0581 mL 2.6453 mL
25 mM 0.0846 mL 0.4232 mL 0.8465 mL 2.1162 mL
30 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
40 mM 0.0529 mL 0.2645 mL 0.5291 mL 1.3226 mL
50 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0581 mL
60 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8818 mL
80 mM 0.0265 mL 0.1323 mL 0.2645 mL 0.6613 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5291 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxystilbamidine bis(methanesulfonate)223769-64-0Fluorescent DyeInhibitorinhibitorinhibit

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