2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Indoleamine 2,3-Dioxygenase (IDO) HDAC
  4. IDO1 and HDAC1 Inhibitor

IDO1 and HDAC1 Inhibitor (Compound 10) 是双重 IDO1 和 HDAC1 抑制剂，IC50 分别为 69.0 nM 和 66.5 nM。

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IDO1 and HDAC1 Inhibitor Chemical Structure

IDO1 and HDAC1 Inhibitor Chemical Structure

CAS No. : 2227044-16-6

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IDO1 and HDAC1 Inhibitor 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC50s of 69.0 nM and 66.5 nM, respectively[1].

IC50 & Target[1]

IDO1

69.0 nM (IC50)

HDAC1

66.5 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 EC50
0.17 μM
Compound: 83
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay
[PMID: 33569941]
A549 IC50
16.73 μM
Compound: 10
Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
CT26 IC50
59.84 μM
Compound: 10
Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
HCT-116 EC50
5.1 μM
Compound: 83
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by MTT assay
[PMID: 33569941]
HCT-116 IC50
5.12 μM
Compound: 10
Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
HT-29 IC50
11.71 μM
Compound: 10
Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
Lewis lung carcinoma cell line IC50
17.62 μM
Compound: 10
Antiproliferative activity against mouse LLC cells after 48 hrs by CCK-8 assay
Antiproliferative activity against mouse LLC cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
Lewis lung carcinoma cell line EC50
18 μM
Compound: 83
Antiproliferative activity against mouse Lewis lung carcinoma cell line cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against mouse Lewis lung carcinoma cell line cells assessed as inhibition of cell proliferation by MTT assay
[PMID: 33569941]
分子量

597.40

Formula

C25H22BrFN8O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDO1 and HDAC1 Inhibitor 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1 and HDAC1 Inhibitor2227044-16-6Indoleamine 2,3-Dioxygenase (IDO)HDACHistone deacetylasesInhibitorinhibitorinhibit

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