2. MAPK/ERK Pathway Autophagy Anti-infection
  3. p38 MAPK Autophagy HCV
  4. ITX5061

ITX5061 是 一个 II 型 p38 MAPK 抑制剂，也是清道夫受体 B1 (SR-B1) 的拮抗剂。

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ITX5061 Chemical Structure

ITX5061 Chemical Structure

CAS No. : 1252679-52-9

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规格 价格 是否有货 数量
1 mg ￥2600
In-stock
5 mg ￥5200
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

ITX5061 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

IC50 & Target

p38 MAPK, SR-B1[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
0.77 μM
Compound: ITX-5061
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of [3H]cholesteryl ester uptake into cells after 2 to 3 hrs by liquid scintillation counting
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of [3H]cholesteryl ester uptake into cells after 2 to 3 hrs by liquid scintillation counting
[PMID: 25900219]
体内研究
(In Vivo)

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P<0.05), while calculated production rates are identical in both groups (129±24 μg/g/d vs 129±16 μg/g/d). Moreover, accumulation of [3H] CE in the liver is significantly lower in ITX5061-treated mice indicating that increased HDL-CE levels are due to reduced uptake by the liver[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

620.16

Formula

C30H38ClN3O7S
CAS 号
性状

固体

颜色

Light yellow to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 83.3 mg/mL (134.32 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6125 mL 8.0624 mL 16.1249 mL
5 mM 0.3225 mL 1.6125 mL 3.2250 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.38%

COA (268 KB) LCMS (111 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1]

Atherosclerosis studies are conducted in F1 hybrid C57BL/6×DBA/1 Ldlr+/- mice fed the Paigen diet, which is high-fat/cholesterol/bile salt diet containing 1.25% cholesterol, 7.5% cocoa butter, and 0.5% cholic acid. For 18 weeks, the mice are put on the Paigen diet with or without ITX5061 at 0.037 %. CETP expression is induced by injection of adeno-associated virus (AAV)8 TBG human CETP vector two weeks before starting the Paigen diet. Doses of virus are given by IP injection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

ITX5061 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6125 mL 8.0624 mL 16.1249 mL 40.3122 mL
5 mM 0.3225 mL 1.6125 mL 3.2250 mL 8.0624 mL
10 mM 0.1612 mL 0.8062 mL 1.6125 mL 4.0312 mL
15 mM 0.1075 mL 0.5375 mL 1.0750 mL 2.6875 mL
20 mM 0.0806 mL 0.4031 mL 0.8062 mL 2.0156 mL
25 mM 0.0645 mL 0.3225 mL 0.6450 mL 1.6125 mL
30 mM 0.0537 mL 0.2687 mL 0.5375 mL 1.3437 mL
40 mM 0.0403 mL 0.2016 mL 0.4031 mL 1.0078 mL
50 mM 0.0322 mL 0.1612 mL 0.3225 mL 0.8062 mL
60 mM 0.0269 mL 0.1344 mL 0.2687 mL 0.6719 mL
80 mM 0.0202 mL 0.1008 mL 0.2016 mL 0.5039 mL
100 mM 0.0161 mL 0.0806 mL 0.1612 mL 0.4031 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITX50611252679-52-9ITX 5061ITX-5061p38 MAPKAutophagyHCVHepatitis C virusInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-19900
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