2. Immunology/Inflammation
  3. Nuclear Factor of activated T Cells (NFAT)
  4. KRN2

KRN2 是选择性的 T 细胞激活核因子 (NFAT5) 的抑制剂，IC50 值为 100 nM。KRN2 有潜力用于 NFAT5-介导的慢性关节炎的潜能。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 KRN2 bromide 通常具有更好的水溶性和稳定性。

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KRN2 Chemical Structure

KRN2 Chemical Structure

CAS No. : 248260-75-5

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KRN2 的其他形式现货产品:

Customer Review

Other Forms of KRN2:

KRN2 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM. KRN2 has potential to treat NFAT5-mediated Chronic Arthritis[1].

IC50 & Target

IC50: 100 nM (NFAT5)[1].
体外研究
(In Vitro)

KRN2 selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions[1].
KRN2 dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRN2 相关抗体:
体内研究
(In Vivo)

KRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role[1].
KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old C57BL/6 mice injected intradermally with 2 mg of complete Freund's adjuvant[1].
Dosage: 3 mg/kg.
Administration: Peritoneally (i.p.) daily for 2 weeks.
Result: Effective in suppressing AIA.
Animal Model: 8-week-old DBA/1Jmice immunized with bovine type II collagen[1].
Dosage: 3 mg/kg.
Administration: Peritoneally (i.p.) daily.
Result: Effective in suppressing CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.
分子量

479.93

Formula

C27H23ClFNO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRN2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRN2248260-75-5KRN 2KRN-2Nuclear Factor of activated T Cells (NFAT)Inhibitorinhibitorinhibit

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产品名称：
KRN2
目录号：
HY-112125
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