2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species Endogenous Metabolite
  4. Lycopene

Lycopene  (Synonyms: 番茄红素)

目录号: HY-N0287 纯度: 98.44%
COA 产品使用指南

摩尔计算器

Lycopene是番茄，番茄产品和其他红色水果和蔬菜中天然存在的类胡萝卜素; 具有抗氧化作用。

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Lycopene Chemical Structure

Lycopene Chemical Structure

CAS No. : 502-65-8

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规格 价格 是否有货 数量
5 mg ￥660
In-stock
10 mg ￥990
In-stock
25 mg ￥1600
In-stock
50 mg ￥2400
In-stock
100 mg   询价  
200 mg   询价  

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Customer Review

Other Forms of Lycopene:

Lycopene 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.

IC50 & Target

Human Endogenous Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Platelet IC50
5.8 μM
Compound: Lycopene
Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
[PMID: 32463237]
Platelet IC50
6.2 μM
Compound: Lycopene
Inhibition of ADP-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of ADP-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
[PMID: 32463237]
Platelet IC50
6.8 μM
Compound: Lycopene
Inhibition of arachidonic acid-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of arachidonic acid-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
[PMID: 32463237]
体外研究
(In Vitro)

从饮食中摄取足够的 Lycopene 对于从其促进健康的作用中获益是必要的，因为人类无法从头合成 Lycopene。Lycopene 在 1.25 μM 的生理相关浓度下显著抑制前列腺和乳腺癌细胞的生长，并且还会导致细胞中 kappa B 磷酸化抑制剂减少 30-40%[1]。
增加 Lycopene 的摄入量，Lycopene 是西红柿中的一种主要类胡萝卜素，作为全反式异构体食用可减弱酒精诱导的 2E1 细胞凋亡，并降低患前列腺癌、肺癌和消化道癌的风险。Lycopene 作为单线态分子氧和过氧自由基清除剂在光氧化过程中起到保护作用，并且可以与其他抗氧化剂协同作用[2]。
作为类胡萝卜素的 Lycopene 可以通过三种不同的机制与活性氧 (ROS) 类型发生反应：I) 通过电子转移，II) 通过氢原子转移或 III) 通过加合物形成。Lycopene 主要通过物理淬灭使单线态氧失活[3]。
Lycopene 通过抑制 PKC 通路中产生的 NADPH 氧化酶来降低 SK-Hep-1 细胞中 ROS 的产生[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lycopene 相关抗体:
体内研究
(In Vivo)

Lycopene 是人体血浆中最主要的类胡萝卜素，半衰期约为 2-3 天[2]。
Lycopene 或加工过的西红柿可能会导致血管壁内膜中层厚度减少[3]。
Lycopene 对大鼠肾上腺皮质中 ATZ 诱导的毒性发挥保护作用。这些作用可能归因于 Lycopene 的抗氧化特性及其激活 Nrf2/HO-1 通路的能力[4]。
Lycopene 作为抗氧化剂改善肝毒性，降低 GSSG 并调节 tGSH 和 CAT 水平，减少氧化损伤[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

536.87

Formula

C40H56
CAS 号
性状

固体

颜色

Purple to red

中文名称

番茄红素；茄红素；西红柿红素
结构分类
初始来源
运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light, stored under nitrogen
溶解性数据
细胞实验： 

THF 中的溶解度 : 5 mg/mL (9.31 mM; 超声助溶)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8626 mL 9.3132 mL 18.6265 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months (protect from light, stored under nitrogen)。-80°C 储存时，请在6个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.44%

COA (278 KB) RP-HPLC (247 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

PC3 cells and MDA-MB-231 cells are treated with (0, 0.5, 1.25, 2.5 and 5 μM) lycopene for 48 h. Cell survival/growth is measured using the colorimetric MTS assay method. MTS-PMS complex (20 μL) is added to each well. The catalytic activity of viable cells results in formazan dye production, which is then quantified. Cells are incubated with the dye for 1 h, followed by absorbance reading at 492 nm on a spectrophotometer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4]

Rats: Lycopene is dissolved in corn oil. 35 adult male albino rats are randomized into five equal groups: untreated control, vehicle control (receives 0.5 mL corn oil/day), lycopene (10 mg/kg b.w./day), ATZ (dissolved in 0.5 mL corn oil 300 mg/kg b.w./day), and ATZ + lycopene. All treatments are given by oral gavage for 4 weeks[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Lycopene 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months (protect from light, stored under nitrogen)。-80°C 储存时，请在6个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
THF 1 mM 1.8626 mL 9.3132 mL 18.6265 mL 46.5662 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL 9.3132 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lycopene502-65-8番茄红素茄红素西红柿红素Reactive Oxygen SpeciesEndogenous MetaboliteInhibitorinhibitorinhibit

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