Microcystin-LR  (Synonyms: Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa))

Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC₅₀s of 1.7 nM and 0.04 nM, respectively.

IC50: 1.7 nM (PP1), 0.04 nM (PP2A)^[1].

Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication^[2]. Microcystin-LR proves to be a potent inhibitor of type 1 (IC₅₀=1.7 nM) and type 2A (IC₅₀= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

995.17

C₄₉H₇₄N₁₀O₁₂

101043-37-2

液体

Colorless to light yellow

ADALD-{Bas}-R-{Oaa}-D-{Ggu}

微囊藻毒素-LR

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Honkanen RE, et al. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem. 1990 Nov 15;265(32):19401-4.  [Content Brief]

  [2]. Lone Y, et al. Microcystin-LR Induced Immunotoxicity in Mammals. J Toxicol. 2016:8048125.  [Content Brief]