Motilin (26-47), human, porcine  (Synonyms: 胃动素 (人类，猪))

Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with K_i and EC₅₀ of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)^[1]
Ki: 2.3 nM (motilin receptor, Chinese hamster ovary cell)^[1]

[Bpa¹，Ile¹³]motilin 是 motilin 受体的完全激动剂，以浓度依赖性方式增加细胞内钙 (EC₅₀=1.5 ± 0.4 nM)^[1]。Motilin 以高亲和力 (IC₅₀ 0.7± 0.2 nM) 与平滑肌细胞上的受体结合。促胃动素选择性激活 G (q) 和 G (13)，刺激 G α (q) 依赖性磷酸肌醇 (PI) 水解和 1，4，5-三磷酸 (IP (3) ) 依赖性 Ca²⁺ 释放，并增加胞质游离 Ca²⁺。胃动素诱导双相、浓度依赖性收缩 (EC₅₀=1.0 +/- 0.2 nM)，包括初始峰值和随后的持续收缩^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2699.07

C₁₂₀H₁₈₈N₃₄O₃₅S

52906-92-0

固体

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Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln

FVPIFTYGELQRMQEKERNKGQ

胃动素 (人类，猪)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Coulie B, et al. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J Biol Chem. 2001 Sep 21;276(38):35518-22. Epub 2001 Jul 18.  [Content Brief]

  [2]. Huang J, et al. Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G23-31.  [Content Brief]