2. GPCR/G Protein
  3. Leukotriene Receptor
  4. ONO4057

ONO4057  (Synonyms: ONO-LB457)

目录号: HY-U00252
产品使用指南

摩尔计算器

ONO4057 是 Leukotriene B4 受体的拮抗剂，其 IC50 值为 0.7±0.3 μM。

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ONO4057 Chemical Structure

ONO4057 Chemical Structure

CAS No. : 134578-96-4

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Customer Review

ONO4057 相关抗体

Top Publications Citing Use of Products

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.

IC50 & Target[1]

LTB4

0.7 μM (IC50)

体内研究
(In Vivo)

Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

470.55

Formula

C27H34O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[2]

Inbred male ACI (180 to 210 g) and LEW (200 to 240 g) rats are used as donors and recipients. Liver transplantation is orthotopically performed. ONO4057 dissolved in 7% NaHCO3 or solvent is administered subcutaneously daily after transplantation. Animals are divided into two groups: group I (n=5), 7% NaHCO3 3 mL/kg as controls; group II (n=6), ONO4057 30 mg/kg per day[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

ONO4057 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO4057134578-96-4ONO-LB457ONO 4057ONO-4057Leukotriene ReceptorInhibitorinhibitorinhibit

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