2. Apoptosis
  3. Apoptosis
  4. Osajin

Osajin  (Synonyms: CID 95168; NSC 21565)

目录号: HY-N3125 纯度: ≥97.0%
COA 产品使用指南

摩尔计算器

Osajin是 Maclura pomifera 果实中存在的主要生物活性异黄酮，具有抗肿瘤，抗氧化和抗炎活性。

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Osajin Chemical Structure

Osajin Chemical Structure

CAS No. : 482-53-1

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1 mg ￥3100
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Osajin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera with antitumor, antioxidant and anti-inflammatory activities.

IC50 & Target

Apoptosis[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ACHN GI50
12.13 μM
Compound: 1, osajin
Growth inhibition of human ACHN cells after 21 hrs by MTT assay
Growth inhibition of human ACHN cells after 21 hrs by MTT assay
[PMID: 17662606]
HCT-15 GI50
9.65 μM
Compound: 1, osajin
Growth inhibition of human HCT15 cells after 21 hrs by MTT assay
Growth inhibition of human HCT15 cells after 21 hrs by MTT assay
[PMID: 17662606]
Hepatocyte GI50
> 500 μM
Compound: 1, osajin
Growth inhibition of human hepatocytes after 21 hrs by MTT assay
Growth inhibition of human hepatocytes after 21 hrs by MTT assay
[PMID: 17662606]
LOX IMVI GI50
10.98 μM
Compound: 1, osajin
Growth inhibition of human LOX-IMVI cells after 21 hrs by MTT assay
Growth inhibition of human LOX-IMVI cells after 21 hrs by MTT assay
[PMID: 17662606]
MDA-MB-231 GI50
11.34 μM
Compound: 1, osajin
Growth inhibition of human MDA-MB-231 cells after 21 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 21 hrs by MTT assay
[PMID: 17662606]
NCI-H23 GI50
11.97 μM
Compound: 1, osajin
Growth inhibition of human NCI-H23 cells after 21 hrs by MTT assay
Growth inhibition of human NCI-H23 cells after 21 hrs by MTT assay
[PMID: 17662606]
PC-3 GI50
12.32 μM
Compound: 1, osajin
Growth inhibition of human PC3 cells after 21 hrs by MTT assay
Growth inhibition of human PC3 cells after 21 hrs by MTT assay
[PMID: 17662606]
Vero CC50
11.44 μM
Compound: Osajin
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
10.1101/2020.03.20.999730
Vero IC50
3.87 μM
Compound: Osajin
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
10.1101/2020.03.20.999730
体外研究
(In Vitro)

Osajin significantly decreases the viability of human NPC cells (TW076, CG1 and TW04 cells) in a dose-dependent manner. Osajin induces apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress[1]. Osajin exhibits growth inhibitory activity on six human cancer cell lines, including kidney, lung, prostate, breast, melanoma and colon cancer cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Osajin 相关抗体:
体内研究
(In Vivo)

Osajin and pomiferin attenuates the myocardial dysfunction provoked by ischemia reperfusion. This is confirmed by an increase in both antioxidant enzyme values and total antioxidant activity. The cardioprotection provided by osajin and pomiferin treatment results from the suppression of oxidative stress and this correlates with improved ventricular function[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

404.46

Formula

C25H24O5
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥97.0%

COA (267 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

NPC cells are seeded in 96-well plates (5000/well) and allowed to adhere for 24 h. The medium is then substituted by a fresh one containing different concentrations (0.01–10 µM) of osajin for another 24 h. For the time-course assay, the incubation times with 5 µM of osajin are 6, 12, 24, 36 and 48 h. After incubation, 10 µl of 5 mg/ml of MTT is added to each well and incubated for 4 h at 37°C. Cell viability is determined using the MTT-based assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Rats[1]

The Wistar rats are divided into four groups. The first treatment group receives osajin (5 mg/kg/day in 0.5% Avicel); the second treatment group receives pomiferin (5 mg/kg/day in 0.5% Avicel); the placebo group receives only 0.5 Avicel; the last is an untreated control group. Biochemical indicator of oxidative damage-lipid peroxidation product malondialdehyde, antioxidant enzymes-superoxide dismutase, glutathione peroxidase, total antioxidant activity in serum and myocardium are evaluated. The effect of osajin and pomiferin on cardiac function, left ventricular end-diastolic pressure, left ventricular pressure and peak positive +dP/dt ischemia and reperfusion, also is examined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Osajin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Osajin482-53-1CID 95168 NSC 21565CID95168CID-95168NSC21565NSC 21565NSC-21565ApoptosisInhibitorinhibitorinhibit

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