2. Anti-infection
  3. Antibiotic Bacterial
  4. Ibafloxacine

Ibafloxacine  (Synonyms: 依巴沙星; R835; S25930)

目录号: HY-U00214
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摩尔计算器

Ibafloxacine (R835) 是一种专门用于兽医用途的氟喹诺酮类抗生素。

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Ibafloxacine Chemical Structure

Ibafloxacine Chemical Structure

CAS No. : 91618-36-9

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Ibafloxacine 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ibafloxacine (R835) is a fluoroquinolone antibiotic agent that is developed exclusively for veterinary use.

IC50 & Target

Quinolone

 

体内研究
(In Vivo)

The pharmacokinetic behavior of Ibafloxacin is studied after intravenous administration of a single dose of 15 mg/kg to 6 healthy lactating goats. Plasma concentrations of Ibafloxacin are determined by high-performance liquid chromatography with fluorescence detection. After IV injection Ibafloxacin shows very rapid initial distribution, with a mean half-life of 0.35 h, follows by slower elimination, with a mean half-life of 3.76 h. The elimination half-life of Ibafloxacin after oral administration has been reported to be 3.83 h in dogs and 3.00 h in cats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

275.27

Formula

C15H14FNO3
CAS 号
中文名称

依巴沙星
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Goats[1]
Six Murciano-Granadina female goats 52 to 58 kg in body weight (BW) and 3 to 4 y of age are used. A 5% aqueous solution of Ibafloxacin is prepared from the pure substance and sterilized. The solution is administered by the IV route as a single dose of 15 mg/kg BW. Blood samples (4 mL) are collected from the contralateral jugular vein into heparinized tubes at 0, 5, 10, 15, 30, and 45 min and at 1, 1.5, 2, 4, 6, 8, 10, 12, 24, 32, 48, and 72 h after drug administration. The samples are centrifuged at 1500× g for 15 min, and then the plasma is removed and stored at -45°C until assayed. Milk samples are collected before and at 1, 2, 4, 6, 12, 24, 32, 48, and 72 h after complete evacuation of the udder at each collection period. The concentration of Ibafloxacin is measured in plasma and milk by a modified high-performance liquid chromatography (HPLC) method.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Ibafloxacine 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Ibafloxacine91618-36-9R835 S25930依巴沙星R 835R-835S25930S 25930S-25930AntibioticBacterialInhibitorinhibitorinhibit

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