2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB-269970

SB-269970 是一种有效、选择性和可透过血脑屏障的 5-HT7 受体拮抗剂，pKi 为 8.3，对 5-HT7 受体选择性大于其他 5-HT 受体。

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SB-269970 Chemical Structure

SB-269970 Chemical Structure

CAS No. : 201038-74-6

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规格 价格 是否有货 数量
5 mg ￥842
In-stock
10 mg ￥1348
In-stock
25 mg ￥2790
In-stock
50 mg ￥4464
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of SB-269970:

SB-269970 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors[1][2].

IC50 & Target

Human 5-HT7 Receptor

8.3 (pKi)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
3.71 nM
Compound: SB-269970
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
[PMID: 27475109]
体内研究
(In Vivo)

SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL6/J mice[2]
Dosage: 3, 10, 30 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly blocked amphetamine and ketamine-induced hyperactivity.
分子量

352.49

Formula

C18H28N2O3S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (283.70 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8370 mL 14.1848 mL 28.3696 mL
5 mM 0.5674 mL 2.8370 mL 5.6739 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SB-269970 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8370 mL 14.1848 mL 28.3696 mL 70.9240 mL
5 mM 0.5674 mL 2.8370 mL 5.6739 mL 14.1848 mL
10 mM 0.2837 mL 1.4185 mL 2.8370 mL 7.0924 mL
15 mM 0.1891 mL 0.9457 mL 1.8913 mL 4.7283 mL
20 mM 0.1418 mL 0.7092 mL 1.4185 mL 3.5462 mL
25 mM 0.1135 mL 0.5674 mL 1.1348 mL 2.8370 mL
30 mM 0.0946 mL 0.4728 mL 0.9457 mL 2.3641 mL
40 mM 0.0709 mL 0.3546 mL 0.7092 mL 1.7731 mL
50 mM 0.0567 mL 0.2837 mL 0.5674 mL 1.4185 mL
60 mM 0.0473 mL 0.2364 mL 0.4728 mL 1.1821 mL
80 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8865 mL
100 mM 0.0284 mL 0.1418 mL 0.2837 mL 0.7092 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-269970201038-74-6SB269970SB 2699705-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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目录号：
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