2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. SKF-82958

SKF-82958  (Synonyms: (±)-SKF-82958; Chloro-APB)

目录号: HY-10435
产品使用指南

摩尔计算器

SKF-82958 ((±)-SKF 82958) 是多巴胺 D1 受体激动剂 (K0.5=4 nM)，对 D1 受体有选择性(K0.5=73 nM)。SKF-82958 诱导大鼠纹状体膜多巴胺 D1 受体依赖性腺苷酸环化酶活性(EC50=491 nM)。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 SKF-82958 hydrobromide 通常具有更好的水溶性和稳定性。

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SKF-82958 Chemical Structure

SKF-82958 Chemical Structure

CAS No. : 80751-65-1

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SKF-82958 的其他形式现货产品:

Other Forms of SKF-82958:

SKF-82958 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM)[1].

体内研究
(In Vivo)

SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[3]
Dosage: 0.5-2.0 mg/kg
Administration: I.p
Result: Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
分子量

329.82

Formula

C19H20ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SKF-82958 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF-8295880751-65-1(±)-SKF-82958 Chloro-APBSKF82958SKF 82958Dopamine ReceptorjawmovementsdiscriminativestimulusantiparkinsonianInhibitorinhibitorinhibit

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