2. Signaling Pathways
  3. Neuronal Signaling
  4. Legumain

Legumain 

Asparaginyl endopeptidase; δ-secretase

Legumain is also known as asparaginyl endopeptidase or δ-secretase. Legumain is a family of cysteine proteases that specifically cleave peptide bonds at their carboxyl-terminal side of Asn or Asp residues. In plants, Legumains are key enzymes in the processing and activation of seed storage proteins during seed maturation. In mammals, Legumain mainly plays its protease activity. Legumain facilitates haemoglobin digestion. Legumain is also involved in processing self and foreign proteins for presentation on the MHCII complex. Besides, Legumain takes part in osteoclast remodeling. Legumain has broad tissue distribution, and is highly expressed in the kidneys, placenta, spleen, bladder, lungs, and thyroid and lymph nodes. Legumain is also overexpressed in cancers and promotes cancer cell migration[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112205A
    RR-11a analog Inhibitor 99.12%
    RR-11a analog 是一种有效且不可逆的 Schistosoma mansoni legumain 抑制剂。其 IC50 为 31 nM。RR-11a analog 是 aza-Asn 的衍生物和 aza-peptide Michael 的受体。
    RR-11a analog
  • HY-128617
    Legumain inhibitor 1 Inhibitor 98.14%
    Legumain inhibitor 1 是一种有效的选择性的 Legumain 抑制剂，IC50 为 3.6 nM。Legumain inhibitor 1 可用于癌症的研究。
    Legumain inhibitor 1
  • HY-112205
    RR-11a Inhibitor
    RR-11a是人工合成的天冬酰胺酰内肽酶 Legumain 抑制剂 (IC50=31-55 nM)。RR-11a 可用于癌症和急性心肌梗死 (AMI) 的研究。
    RR-11a
  • HY-149102
    LE 28
    LE 28 是一种选择性和活性依赖性 legumain 探针。LE 28 只有在结合到活性 legumain 时才会发出荧光。LE 28 可用于癌症和炎症性疾病的研究。
    LE 28
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