2. Others Neuronal Signaling
  3. Fluorescent Dye Legumain
  4. LE 28

LE 28 是一种选择性和活性依赖性 legumain 探针。LE 28 只有在结合到活性 legumain 时才会发出荧光。LE 28 可用于癌症和炎症性疾病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LE 28 Chemical Structure

LE 28 Chemical Structure

CAS No. : 1416080-97-1

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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LE 28 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LE 28 is a selective and activity-dependent legumain probe. LE 28 becomes fluorescent only upon binding active legumain. LE 28 can be used for research of cancers and inflammatory diseases[1].

体外研究
(In Vitro)

LE 28 (0-5 μM, 1 h) 可以通过裂解和荧光 SDS-PAGE 标记法检测 RAW 细胞裂解物中的 legumain[1]。
LE 28 (1 μM, 5 h) 在 RAW 细胞中与 Lysotracker 共定位较好[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LE 28 相关抗体:
体内研究
(In Vivo)

LE 28 (2 mg/kg, i.v.) 在小鼠肾脏中产生特异性信号[1]。
LE 28 (2 mg/kg, i.v.) 在 HCT-116 异种移植肿瘤模型中 30 分钟时在肿瘤周围检测到信号，7 小时后肿瘤与正常组织之间的信噪比达到最大[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT-116 xenograft tumor model[1]
Dosage: 2 mg/kg
Administration: i.v.
Result: Detected the signal around the periphery of the tumors in as early as 30 min, with maximal contrast between tumor and normal tissue achieved after seven hours, and the signal remained constant up to 28 h.
分子量

1909.22

Formula

C102H111N10O21S3+
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LE 28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LE 281416080-97-1LE28LE-28Fluorescent DyeLegumainAsparaginyl endopeptidaseδ-secretaseprobefluorescentcancerinflammatory diseaseInhibitorinhibitorinhibit

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