Neuropeptide S Receptor (神经肽 S 受体)

Neuropeptide S Receptor (NPSR) is a member of the G protein-coupled receptor (GPCR) superfamily and serves as the specific receptor for neuropeptide S (NPS). Upon binding to NPS, which occurs with high affinity, NPSR activates both Gq and Gs proteins, resulting in increased intracellular calcium levels and cyclic adenosine monophosphate (cAMP) accumulation. NPSR is predominantly expressed in brain regions associated with anxiety and stress responses, including the amygdaloid complex, paraventricular hypothalamic nucleus, and hippocampus. This receptor plays significant roles in various physiological processes, including inflammation, nociception, locomotor activity, wakefulness, anxiety regulation, and food intake, and is particularly implicated in the pathogenesis of asthma^[1][2].