Nucleoside Transporters (核苷转运体)

Nucleoside transporters (NTs) are a class of transmembrane proteins responsible for mediating the transmembrane transport of nucleosides and nucleoside analogs. They are widely expressed in mammalian cells and are classified into two major families based on their transport mechanisms and substrate specificities: equilibrative nucleoside transporters (ENTs/SLC29) and concentrative nucleoside transporters (CNTs/SLC28). ENTs have four subtypes (hENT1-4), which passively transport nucleosides through concentration gradients. CNTs have three subtypes (hCNT1-3), which actively uptake nucleosides dependent on sodium ion gradients.
Nucleoside transporters can be used in research on cardiovascular diseases, cancer, and viral diseases^[1][2][3].