2. Epigenetics
  3. Histone Methyltransferase
  4. UNC0379 TFA

UNC0379 TFA 是一个选择性的底物竞争性的赖氨酸甲基转移酶 SETD8 (KMT5A) 抑制剂，IC50 值为 7.3 μM，KD 值 of 18.3 μM。UNC0379 TFA 可用于炎症癌症的研究，如肺纤维化，卵巢癌，神经母细胞瘤。

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UNC0379 TFA Chemical Structure

UNC0379 TFA Chemical Structure

CAS No. : 1620401-83-3

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货
2 mg ￥650
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5 mg ￥1000
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UNC0379 TFA 的其他形式现货产品:

Other Forms of UNC0379 TFA:

UNC0379 TFA 相关抗体

Top Publications Citing Use of Products

    UNC0379 TFA purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129.  [Abstract]

    The effects of treatment with the indicated epigenetic inhibitors on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.

    查看 Histone Methyltransferase 亚型特异性产品:

    查看所有亚型
    EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 TFA can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma[1][2][3].

    IC50 & Target

    SETD8 (KMT5A)[1]
    体外研究
    (In Vitro)

    UNC0379 TFA (1-10 μM, 9 days) inhibits HGSOC cells proliferation[2].
    UNC0379 TFA (10 μM, 96 h) increases in the proportion of sub-G1 phase cells in HGSOC cells[2].
    UNC0379 TFA (10 μM, 48 h) induces myofibroblast de-differentiation and inhibits additional fibroblast to myofibroblast differentiation[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    UNC0379 TFA 相关抗体:

    Cell Viability Assay[1]

    Cell Line: JHOS2, JHOS3, JHOS4, OVCAR3, OVCAHO, OVKATE, KURAMOCHI, TYKnu
    Concentration: 1-10 μM
    Incubation Time: 9 days
    Result: Inhibited HGSOC cells proliferation with IC50s ranging from 0.39 to 3.20 µM.

    Cell Cycle Analysis[1]

    Cell Line: JHOS3, OVCAR3
    Concentration: 10 µM
    Incubation Time: 96 h
    Result: Arrested cells in sub-G1 phase.
    体内研究
    (In Vivo)

    UNC0379 TFA (intratracheal administration, 1 mg/kg/day, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Bleomycin (BLM)-induced lung fibrosis mouse model[3]
    Dosage: 1 mg/kg/day
    Administration: Intratracheal administration, on day7, 8, and 9.
    Result: Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation.
    分子量

    527.58

    Formula

    C25H36F3N5O4
    CAS 号
    性状

    固体

    颜色

    Light yellow to khaki

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 100 mg/mL (189.54 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.8954 mL 9.4772 mL 18.9545 mL
    5 mM 0.3791 mL 1.8954 mL 3.7909 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.91%

    COA (251 KB)

    产品使用指南 (1538 KB)
    参考文献

    UNC0379 TFA 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.8954 mL 9.4772 mL 18.9545 mL 47.3862 mL
    5 mM 0.3791 mL 1.8954 mL 3.7909 mL 9.4772 mL
    10 mM 0.1895 mL 0.9477 mL 1.8954 mL 4.7386 mL
    15 mM 0.1264 mL 0.6318 mL 1.2636 mL 3.1591 mL
    20 mM 0.0948 mL 0.4739 mL 0.9477 mL 2.3693 mL
    25 mM 0.0758 mL 0.3791 mL 0.7582 mL 1.8954 mL
    30 mM 0.0632 mL 0.3159 mL 0.6318 mL 1.5795 mL
    40 mM 0.0474 mL 0.2369 mL 0.4739 mL 1.1847 mL
    50 mM 0.0379 mL 0.1895 mL 0.3791 mL 0.9477 mL
    60 mM 0.0316 mL 0.1580 mL 0.3159 mL 0.7898 mL
    80 mM 0.0237 mL 0.1185 mL 0.2369 mL 0.5923 mL
    100 mM 0.0190 mL 0.0948 mL 0.1895 mL 0.4739 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    UNC03791620401-83-3UNC 0379UNC-0379Histone MethyltransferaseOvarian cancerlysine methyltransferaseantitumorHGSOCOVCAR3JHOS3neuroblastomapulmonary fibrosisInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
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