2. 多肽产品
  3. 多肽及其衍生物
  4. 多肽药物递送
  5. 细胞穿膜肽
  6. (Arg)9

(Arg)9  (Synonyms: Nona-L-arginine; Peptide R9)

目录号: HY-P0133
产品使用指南

摩尔计算器

(Arg)9 (Nona-L-arginine) 是一种由 9 个精氨酸残基组成的细胞穿透肽 (CPP)。(Arg)9 具有神经保护功能，在谷氨酸模型中 IC50 值为 0.78 μM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 (Arg)9 acetate 通常具有更好的水溶性和稳定性。

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Custom Peptide Synthesis

(Arg)9 Chemical Structure

(Arg)9 Chemical Structure

CAS No. : 143413-47-2

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     可免费申领三个不同产品的试用装。

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规格 是否有货
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(Arg)9 的其他形式现货产品:

Customer Review

Other Forms of (Arg)9:

(Arg)9 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2].

IC50 & Target

IC50: 0.78 μM (neuroprotection)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: p-03
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
[PMID: 35452935]
BEAS-2B IC50
> 100 μM
Compound: p-03
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
[PMID: 35452935]
HepG2 IC50
> 100 μM
Compound: p-03
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
[PMID: 35452935]
L02 IC50
> 100 μM
Compound: p-03
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
[PMID: 35452935]
体外研究
(In Vitro)

(Arg)9 (Nona-L-arginine; 5-10 μM) provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Arg)9 相关抗体:
体内研究
(In Vivo)

(Arg)9 (Nona-L-arginine; 1 μM/kg (600  μL); i.v.; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) shows neuroprotective effects and reduces infarct volume[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague–Dawley rats (270 to 320 g) permanent middle cerebral artery stroke model[2]
Dosage: 1 μM/kg (600  μL)
Administration: Intravenous injection; once, over 5 minutes
Result: Reduced significantiy 20% in infarct volume.
分子量

1423.69

Formula

C54H110N36O10
CAS 号
Sequence

Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
Sequence Shortening

RRRRRRRRR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

(Arg)9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Arg)9143413-47-2Nona-L-arginine Peptide R9Peptide R9Peptide R 9Peptide R-9Otherscell-penetrating peptideneuroprotective propertyarginineinfarct volumeInhibitorinhibitorinhibit

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产品名称：
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目录号：
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