2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. A-331440

A-331440 是一种强效且选择性的组胺 H3 受体拮抗剂，可通过抑制突触前 H3 受体来调节神经递质释放。在涉及高脂饮食小鼠的临床前研究中，A-331440 显示出剂量依赖性的减重和减脂效果。在 5 mg/kg 剂量下，它可有效降低体重，效果堪比右芬氟拉明；而在 15 mg/kg 剂量下，它可显著减少体脂并改善胰岛素耐受性，效果与低脂饮食小鼠相似。这些研究结果表明，A-331440 有望通过调节与食物摄入和代谢调节有关的组胺能通路，成为一种抗肥胖试剂。

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A-331440 Chemical Structure

A-331440 Chemical Structure

CAS No. : 392338-13-5

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A-331440 相关抗体

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查看 Histamine Receptor 亚型特异性产品:

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

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生物活性

A-331440 is a potent and selective histamine H3 receptor antagonist that regulates neurotransmitter release by inhibiting presynaptic H3 receptors. In preclinical studies involving mice on a high-fat diet, A-331440 demonstrated dose-dependent effects on weight reduction and fat loss. At 5 mg/kg, it effectively decreased body weight comparable to dexfenfluramine, while at 15 mg/kg, it significantly reduced body fat and improved insulin tolerance, similar to mice on a low-fat diet. These findings suggest that A-331440 holds promise as an antiobesity agent by modulating histaminergic pathways involved in food intake and metabolic regulation[1].

分子量

349.47

Formula

C22H27N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A-331440 相关分类

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  • 稀释计算器

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Keywords:

A-331440392338-13-5A331440A 331440Histamine ReceptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-12191
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