1. Apoptosis
  2. Caspase Apoptosis
  3. Ac-DEVD-CMK

Ac-DEVD-CMK  (Synonyms: Caspase-3 Inhibitor III)

目录号: HY-P0034
产品使用指南

Ac-DEVD-CMK (Caspase-3 Inhibitor III) 是一种选择性且不可逆的 caspase-3 抑制剂。Ac-DEVD-CMK 显着抑制由高水平葡萄糖或 3,20-dibenzoate (IDB; HY-137295) 诱导的凋亡。Ac-DEVD-CMK 可以用于多种实验方法以抑制细胞凋亡。

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Custom Peptide Synthesis

Ac-DEVD-CMK Chemical Structure

Ac-DEVD-CMK Chemical Structure

CAS No. : 285570-60-7

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Ac-DEVD-CMK 的其他形式现货产品:

Customer Review

Other Forms of Ac-DEVD-CMK:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis[1][2][3].

IC50 & Target[1][2]

Caspase-3

 

体外研究
(In Vitro)

Ac-DEVD-CMK (100 μM; 24 h) 抑制 IDB 诱导的细胞凋亡[3]
Ac-DEVD-CMK (10 μM; 36 h) 抑制人咽鳞癌 FaDu 和 Detroit 562 细胞系中柠檬酸盐 (10 mM) 诱导的 p21 裂解和 G2/M 积累[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[3]

Cell Line: Jurkat cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Inhibited ingenol IDB (10 μM)-induced apoptosis.
体内研究
(In Vivo)

Ac-DEVD-CMK (Caspase-3 Inhibitor III;25 mg/kg;腹腔注射;单剂量;APAP 后 3 小时) 显着减弱对乙酰氨基酚 (APAP;HY-66005) 诱导的肝损伤 (AILI)[5]
Ac-DEVD-CMK (25 mg/kg;ip;单剂量) 显著减轻易感 Sdc1−/− 小鼠中 APAP 诱导的肝损伤 (AILI)[6]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6- to 8-week-old females and males Sdc1-/- mice[4]
Dosage: 25 mg/kg
Administration: IP; single dose; 3 hours post-APAP
Result: Significantly attenuated APAP (ip; 500 or 625 mg/kg)-induced liver injury (AILI), indicating that inhibition of GSK-3β or caspase-3 activity mitigates liver damage.
分子量

550.94

Formula

C21H31ClN4O11

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ac-DEVD-CMK
目录号:
HY-P0034
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