AC-VEID-CHO TFA 

AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease^[1].

AC-VEID-CHO (TFA) has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively^[1].
Ac-VEID-CHO is predominantly excluded from accessing the intracellular environment (0.16% cellular accumulation) and lacks any activity with an IC₅₀ value of ＞100 μM in the cellular assay^[1].
AC-VEID-CHO (TFA) (also inactive in lamin degradation assay) is clearly able to inhibit VEIDase activity with an IC₅₀ value of 0.49 μM when the membrane barrier is removed^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

614.57

C₂₄H₃₇F₃N₄O₁₁

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Robert Mintzer, et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One. 2012;7(1):e30376.  [Content Brief]