2. Inhibitory Antibodies
  3. Acapatamab

Acapatamab  (Synonyms: 艾卡帕妥单抗; AMG-160)

目录号: HY-P99418

摩尔计算器

Acapatamab (AMG-160) 是一种抗 CD3E/FOLH1 的单克隆抗体。

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CAS No. : 2314491-93-3

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Acapatamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Acapatamab (AMG-160) is an anti-CD3E/FOLH1 monoclonal antibody[1].

IC50 & Target

CD3E/FOLH1
体外研究
(In Vitro)

Acapatamab (AMG-160; 0-10000 pM; 48 h) 诱导 T 细胞活化，T 细胞中 CD25、CD69、4-1BB和 PD-1 表达增加[1]。
Acapatamab (0-10000 pM; 48 h; T-cell) 诱导剂量依赖性细胞因子分泌，包括 IL2、IL4、IL6、IL10、IFNγ 和 TNFα[1]。
Acapatamab (0-10000 pM; 48 h) 诱导与 PBMC 共培养的前列腺特异性膜抗原 (PSMA) 阳性前列腺癌细胞系的有效裂解，EC50 值为 6-42 pM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acapatamab 相关抗体:
体内研究
(In Vivo)

Acapatamab (0.02-2 mg/kg; i.v.; 第 16, 23 和 31 天) 具有抗肿瘤活性，并抑制 NOD/SCID 小鼠 22Rv-1 CRPC 异种移植瘤的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice with 22Rv-1 CRPC xenografts[1]
Dosage: 0.02, 0.2, and 2 mg/kg
Administration: Intravenous injection (days 16, 23, and 31)
Result: Had antitumor activity against established CRPC tumors.
CAS 号
中文名称

艾卡帕妥单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc
纯度 & 产品资料
参考文献

Acapatamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acapatamab2314491-93-3AMG-160艾卡帕妥单抗AMG160AMG 160Othershalf-lifecancerT-cellcytokinesprostate-specific membrane antigenInhibitorinhibitorinhibit

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