2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-6

AChE-IN-6 (Compound 12a) 是一种最佳的多功能配体，可显着抑制 AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) 和抗 Aβ 活性 (IC50 = 1.92 μM，用于自诱导 Aβ1-42 聚集；IC50 = 1.80 μM，用于分解 Aβ1-42 原纤维；IC50 = 2.18 μM，用于 Cu2+ 诱导的 Aβ1- 42 聚集；IC50 = 1.17 μM，用于解聚 Cu2+ 诱导的 Aβ1-42 原纤维)。AChE-IN-6 具有阿尔茨海默病研究的潜力。

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AChE-IN-6 Chemical Structure

AChE-IN-6 Chemical Structure

CAS No. : 2758788-95-1

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AChE-IN-6 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease[1].

分子量

491.67

Formula

C29H41N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-62758788-95-1Cholinesterase (ChE)multifunctionalAChEanti-Aβ activityAβ1-42Alzheimer's diseaseInhibitorinhibitorinhibit

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