2. Anti-infection
  3. HSV Antibiotic
  4. Acyclovir monophosphate

Acyclovir monophosphate 是一种有效的抗单纯疱疹病毒 (HSV) 剂。Acyclovir monophosphate 通过抑制病毒 DNA 聚合酶阻断 DNA 合成并终止病毒 DNA 的链延长。Acyclovir monophosphate 显示出抗肿瘤活性。

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Acyclovir monophosphate Chemical Structure

Acyclovir monophosphate Chemical Structure

CAS No. : 66341-16-0

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Other Forms of Acyclovir monophosphate:

Acyclovir monophosphate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero CC50
> 2000 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining
Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining
[PMID: 22954898]
Vero EC50
20 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
[PMID: 22954898]
Vero EC50
41 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
[PMID: 22954898]
分子量

305.18

Formula

C8H12N5O6P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Acyclovir monophosphate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acyclovir monophosphate66341-16-0HSVAntibioticHerpes simplex virusnucleoside analogDNA synthesisantitumorInhibitorinhibitorinhibit

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目录号：
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