2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. ADH-6 TFA

ADH-6 TFA 是一种三吡啶酰胺化合物。ADH-6 TFA 消除了突变 p53 DBD 的聚集成核亚结构域的自组装。ADH-6 TFA 靶向并解离人类癌细胞中的突变 p53 聚集体，从而恢复 p53 的转录活性，导致细胞周期停滞和细胞凋亡 (apoptosis)。ADH-6 TFA 具有研究癌症疾病的潜力。

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ADH-6 TFA Chemical Structure

ADH-6 TFA Chemical Structure

CAS No. : 2990065-87-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥6380
In-stock
1 mg ￥2320
In-stock
5 mg ￥5800
In-stock
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100 mg   询价  

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Customer Review

Other Forms of ADH-6 TFA:

ADH-6 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases[1].

体外研究
(In Vitro)

ADH-6 (25 μM, 10 h) TFA inhibits aggregation of pR248W (indicated by dot blot assay)[1].
ADH-6 (5 μM, 6 h) TFA dissociates intracellular mutant p53 aggregates in MIA PaCa-2 cells[1].
ADH-6 (0-10 μM, 24 or 48 h) TFA causes selective cytotoxicity in cancer cells bearing mutant p53 (MIA PaCa-2)[1].
ADH-6 (5 μM, 24 h) TFA specifically targets and reactivates aggregation-prone mutant p53 in MIA PaCa-2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ADH-6 TFA 相关抗体:

Cell Viability Assay[1]

Cell Line: MIA PaCa-2 (mutant R248W p53), SK-BR-3 (mutant R175H p53)
Concentration: 0, 2.5, 5, 7.5, 10 μM
Incubation Time: 24, 48 h
Result: Caused death of cancer cells bearing mutant, but not WT, p53.

Western Blot Analysis[1]

Cell Line: MIA PaCa-2 cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Increased expression of p53-inducible MDM2 and proapoptotic Bax.
体内研究
(In Vivo)

ADH-6 (intraperitoneal injection, 15 mg/kg, every 2 days, for a total of 12 doses) TFA causes regression of mutant p53-bearing tumors [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MIA PaCa-2 xenografts[1]
Dosage: 716.4 µM in 0.02% DMSO
Administration: Intraperitoneal injection, every 2 days, for a total of 12 doses
Result: Reduced tumor growth relative to the saline-treated control group.
Reduced mutant p53 levels and shrinked xenografts harboring aggregation-prone mutant p53.
Animal Model: MIA PaCa-2 xenografts (pharmacokinetics assay)[1]
Dosage: 15 mg/kg
Administration: Intraperitoneal injection, for a single dose
Result: Cmax: 21 µg/mL, T1/2: 3.6 h
分子量

754.67

Formula

C31H37F3N8O11
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (132.51 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3251 mL 6.6254 mL 13.2508 mL
5 mM 0.2650 mL 1.3251 mL 2.6502 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.91%

COA (174 KB) HNMR (121 KB) RP-HPLC (223 KB) MS (162 KB)

产品使用指南 (1538 KB)
参考文献

ADH-6 TFA 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3251 mL 6.6254 mL 13.2508 mL 33.1271 mL
5 mM 0.2650 mL 1.3251 mL 2.6502 mL 6.6254 mL
10 mM 0.1325 mL 0.6625 mL 1.3251 mL 3.3127 mL
15 mM 0.0883 mL 0.4417 mL 0.8834 mL 2.2085 mL
20 mM 0.0663 mL 0.3313 mL 0.6625 mL 1.6564 mL
25 mM 0.0530 mL 0.2650 mL 0.5300 mL 1.3251 mL
30 mM 0.0442 mL 0.2208 mL 0.4417 mL 1.1042 mL
40 mM 0.0331 mL 0.1656 mL 0.3313 mL 0.8282 mL
50 mM 0.0265 mL 0.1325 mL 0.2650 mL 0.6625 mL
60 mM 0.0221 mL 0.1104 mL 0.2208 mL 0.5521 mL
80 mM 0.0166 mL 0.0828 mL 0.1656 mL 0.4141 mL
100 mM 0.0133 mL 0.0663 mL 0.1325 mL 0.3313 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADH-62990065-87-5ADH6ADH 6MDM-2/p53ApoptosisTripyridylamideself-assemblyp53transcriptionalcell cycleapoptosiscancerInhibitorinhibitorinhibit

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