Adiphenine  (Synonyms: 阿地芬宁)

Adiphenine is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC₅₀s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine has anticonvulsant effects^[1][2][3].

Adiphenine（10 nM-1 mM；3 分钟）在 TE671/RD 细胞中以剂量依赖性方式阻断 α1*-nAChR 的功能，IC₅₀ 为 1.9 μM^[1]。
Adiphenine（10 nM-1 mM；3 分钟）可阻断以下功能：在 SH-SY5Y 细胞中，Adiphenine 以剂量依赖性方式阻断 α3α4*-nAChR，IC₅₀ 为 1.8 μM^[1]。
Adiphenine (10 nM-1 mM；3 分钟) 在 SH-EP1 细胞中以剂量依赖性方式阻断 α4β2- 和 α4β4-nAChR 的功能，IC₅₀ 分别为 3.7 和 6.3 μM^[1]。
Adiphenine (50-200 μM；30-60 秒) 降低 HEK 293 细胞中 ACh 诱导的单通道电流频率^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Adiphenine（腹腔注射）可预防最大电击发作 (MES) 的后腿强直伸肌成分，在小鼠中的 ED₅₀ 为 62 mg/kg^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

311.42

C₂₀H₂₅NO₂

64-95-9

阿地芬宁

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gentry CL, et, al. Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299(3):1038-48.  [Content Brief]

  [2]. Spitzmaul, G., et al., The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol, 2009. 157(5): p. 804-17.  [Content Brief]

  [3]. TANAKA K, et, al. Anticonvulsant properties of procaine, cocaine, adiphenine and related structures. Proc Soc Exp Biol Med. 1955 Oct;90(1):192-5.  [Content Brief]

  [4]. Michelot, J., et al., Adiphenine plasma levels and blood-brain barrier crossing in the rat. Eur J Drug Metab Pharmacokinet, 1985. 10(4): p. 273-8.  [Content Brief]