2. Cell Cycle/DNA Damage Cytoskeleton
  3. PAK
  4. AK963/40708899

AK963/40708899 是一种有效的 PAK1 抑制剂。AK963/40708899 通过下调 PAK1-NF-κB-cyclinB1 通路抑制人胃癌细胞的增殖。AK963/40708899 诱导细胞周期停滞在 G2 期，减少迁移和侵袭。AK963/40708899 抑制丝状伪足的形成并促进细胞粘附，进而通过负向调节 PAK1-LIMKl-cofilin 和 PAK1-ERK-FAK 通路抑制胃细胞的侵袭潜能。

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AK963/40708899 Chemical Structure

AK963/40708899 Chemical Structure

CAS No. : 445007-59-0

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AK963/40708899 相关抗体

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查看 PAK 亚型特异性产品:

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PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1].

IC50 & Target[1]

PAK1

 

分子量

254.33

Formula

C16H18N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AK963/40708899 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AK963/40708899445007-59-0PAKp21 activated kinasesgastric cancer cellPAK1-NF-κB-cyclinB1cycle arrestG2 phasemigrationinvasionfilopodiaPAK1-LIMKl-cofilinPAK1-ERK-FAKInhibitorinhibitorinhibit

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