2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. AKR1B10-IN-1

AKR1B10-IN-1 是一种有效的 AKR1B10 抑制剂，IC50 值为 3.5 nM。AKR1B10-IN-1 抑制顺铂 (Cisplatin) 耐药的肺癌细胞的增殖和转移。

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AKR1B10-IN-1 Chemical Structure

AKR1B10-IN-1 Chemical Structure

CAS No. : 2136579-33-2

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1 mg ￥1520
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5 mg ￥3800
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Customer Review

AKR1B10-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1].

IC50 & Target

3.5 nM (AKR1B10); 277 nM (AKR1B1)[1]
体外研究
(In Vitro)

AKR1B10-IN-1 (compound 4e) (0-20 μM; 96 hours) dose-dependently suppresses the growth of both A549 and A549/1B10 cells[1].
AKR1B10-IN-1 (compound 4e) (0-20 μM; 96 hours) completely suppresses increased cell proliferation by the overexpressing AKR1B10 as well as the endogenous protein[1].
AKR1B10-IN-1 (compound 4e) (0-40 μM; 26 hours; pretreatment with AKR1B10-IN-1 for 2 hours, then incubated with CDDP for 24 hours) decreases the cell viability of CDDP-R-A549 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AKR1B10-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: A549 cells, A549/1B10 cells (AKR1B10-stably overexpressing A549 cells)
Concentration: 0, 10, 20 μM
Incubation Time: 96 hours
Result: Dose-dependently suppressed the growth of both A549 and A549/1B10 cells, and statistically significant at 20 μM.

Cell Viability Assay[1]

Cell Line: CDDP-resistance (cisplatin-resisitance) of A549 cells
Concentration: 0, 10, 20, 40 μM
Incubation Time: Pretreatment with AKR1B10-IN-1 for 2 hours, then incubated with CDDP for 24 hours
Result: Decreased the cell viability of CDDP-R-A549 cells in a dose-dependent manner, and most obvious in the treatment of 40 μM.
分子量

341.33

Formula

C19H16FNO4
CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (292.97 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9297 mL 14.6486 mL 29.2972 mL
5 mM 0.5859 mL 2.9297 mL 5.8594 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

AKR1B10-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9297 mL 14.6486 mL 29.2972 mL 73.2429 mL
5 mM 0.5859 mL 2.9297 mL 5.8594 mL 14.6486 mL
10 mM 0.2930 mL 1.4649 mL 2.9297 mL 7.3243 mL
15 mM 0.1953 mL 0.9766 mL 1.9531 mL 4.8829 mL
20 mM 0.1465 mL 0.7324 mL 1.4649 mL 3.6621 mL
25 mM 0.1172 mL 0.5859 mL 1.1719 mL 2.9297 mL
30 mM 0.0977 mL 0.4883 mL 0.9766 mL 2.4414 mL
40 mM 0.0732 mL 0.3662 mL 0.7324 mL 1.8311 mL
50 mM 0.0586 mL 0.2930 mL 0.5859 mL 1.4649 mL
60 mM 0.0488 mL 0.2441 mL 0.4883 mL 1.2207 mL
80 mM 0.0366 mL 0.1831 mL 0.3662 mL 0.9155 mL
100 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7324 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKR1B10-IN-12136579-33-2Aldose ReductaseAKR1B10anti-cancercisplatin resistancemetastasisproliferationAldo-Keto Reductase 1B10HMPCInhibitorinhibitorinhibit

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产品名称：
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目录号：
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