2. Anti-infection
  3. Fungal
  4. Alexidine

Alexidine 是一种双双胍，对多种真菌病原体具有抗真菌 (antifungal) 和抗生物膜活性。Alexidine 还具有一种抗肿瘤活性，靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶 PTPMT1，并导致线粒体凋亡 (apoptosis)。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Alexidine dihydrochloride 通常具有更好的水溶性和稳定性。

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Alexidine Chemical Structure

Alexidine Chemical Structure

CAS No. : 22573-93-9

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Alexidine 的其他形式现货产品:

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Alexidine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1].

体外研究
(In Vitro)

Alexidine (10 µM, 24 hours) treatment can decimate the biofilm community[1].
Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alexidine 相关抗体:

Cell Viability Assay[1]

Cell Line: C. albicans, C. auris, A. fumigatus
Concentration: 10 µM
Incubation Time: 24 hours
Result: Could significantly kill 80% of mature biofilm community.

Cell Viability Assay[1]

Cell Line: HUVECs, lung A549 cells
Concentration: 0-60 μg/ml
Incubation Time: 24 hours
Result: resulted in 50% killing of HUVECs and lung A549 cells ( CC50 > 7.37 μg/ml ).
体内研究
(In Vivo)

Alexidine (Jugular vein-catheterized; 48 hours; 3 µg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old C57BL/6 male mice
Dosage: 3 µg/ml
Administration: Jugular vein-catheterized, 48 hours, 3 µg/ml, once
Result: Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
分子量

508.79

Formula

C26H56N10
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Alexidine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alexidine22573-93-9Fungalbis-biguanideantibiofilmfungal pathogensanticancermitochondrial tyrosine phosphatasePTPMT1apoptosisCandida albicanspanfungalInhibitorinhibitorinhibit

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