2. Others Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds EGFR Anaplastic lymphoma kinase (ALK) BRK Apoptosis Mitochondrial Metabolism
  4. ALK/EGFR-IN-1-d5

ALK/EGFR-IN-1-d5 (Compound (-)-9a) 是一种 EGFR 和 ALK 的氘代双靶点抑制剂，对 EGFR 的 IC50 值为 1.08 nM，对 ALK 的IC50 值为 2.395 nM。ALK/EGFR-IN-1-d5 通过抑制 EGFR、ALK 和 BRK 信号通路中的磷酸化蛋白来阻断细胞周期，从而导致肿瘤细胞的线粒体膜电位降低和细胞凋亡 (Apoptosis)。ALK/EGFR-IN-1-d5 也可在动物模型中显著抑制肿瘤生长并展现出良好的安全性。ALK/EGFR-IN-1-d5 有望用于抗癌领域的研究。

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ALK/EGFR-IN-1-d5 Chemical Structure

ALK/EGFR-IN-1-d5 Chemical Structure

CAS No. : 2730429-93-1

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ALK/EGFR-IN-1-d5 相关抗体

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  • 生物活性

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生物活性

ALK/EGFR-IN-1-d5 (Compound (-)-9a) is a deuterated dual-target inhibitor of EGFR and ALK, with an IC50 of 1.08 nM for EGFR and an IC50 of 2.395 nM for ALK. ALK/EGFR-IN-1-d5 inhibits the phosphorylated proteins in the EGFR, ALK, and BRK signaling pathways, blocking the cell cycle, leading to a reduction in mitochondrial membrane potential and cell apoptosis (Apoptosis). ALK/EGFR-IN-1-d5 also significantly inhibits tumor growth in animal models and demonstrates good safety. ALK/EGFR-IN-1-d5 holds promise for research in the field of cancer treatment[1]

分子量

577.15

Formula

C27H29D5ClN7O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALK/EGFR-IN-1-d5 相关分类

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Keywords:

ALK/EGFR-IN-1-d52730429-93-1Isotope-Labeled CompoundsEGFRAnaplastic lymphoma kinase (ALK)BRKApoptosisMitochondrial MetabolismEpidermal growth factor receptorErbB-1HER1Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Breast tumor kinaseProtein tyrosine kinase 6 (PTK6)Inhibitorinhibitorinhibit

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