2. Anti-infection
  3. HIV Bacterial
  4. Amustaline dihydrochloride

Amustaline dihydrochloride  (Synonyms: S-303 dihydrochloride)

目录号: HY-106991A 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

Amustaline (S-303) dihydrochloride，一种靶向核酸的烷基化剂，是有效的病原体灭活剂，可用于含有红细胞的血液成分。Amustaline dihydrochloride 具有三个组成部分：吖啶固定物 (非共价靶向核酸的嵌入剂)，效应子 (与亲核试剂反应的双烷基基团) 和连接子 (细的柔性碳链，其中含有不稳定的酯键，在中性 pH 下水解产生非反应性分解产物)。

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Amustaline dihydrochloride Chemical Structure

Amustaline dihydrochloride Chemical Structure

CAS No. : 210584-54-6

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1 mg ￥1818
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5 mg ￥4000
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Amustaline dihydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products)[1][2].

体外研究
(In Vitro)

S‐303 (200 μM; 20 h) and glutathione (GSH; 20 mM) inactivates high titres of Chikungunya virus (CHIKV) in red blood cells (RBCs)[1].
S-303 (200 μM; 20 h) and GSH (2 mM) inactivates >6.5 logs of HIV, >5.7 logs of Bluetongue virus, >7.0 logs of Yersinia enterocolitica, 4.2 logs of Serratia marcescens, and 7.5 logs of Staphylococcus epidermidis in whole blood experiments[2].
S-303 (200 μM; 20 h) and GSH (20 mM) inactivates approximately 5 logs or greater of Y. enterocolitica, E. coli, S. marcescens, S. aureus, HIV, bovine viral diarrhoea virus, bluetongue virus and human adenovirus 5 in RBC[2].
S-303 (200 μM; 20 h) retains in vitro parameters of RBC function and physiology (including total ATP, extracellular potassium, hemolysis, glucose consumption, lactate production, and pH at 37 °C) compared to conventional RBC[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amustaline dihydrochloride 相关抗体:
体内研究
(In Vivo)

S‐303 RBCs (a single transfusion) is well tolerated in rats (50 μmol/kg) and dogs (70 μmol/kg)[3].
S‐303 RBCs (repeated transfusions) is well tolerated in rats (10 μmol/kg) and dogs (10 μmol/kg) with no histopathologic evidence of organ toxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

507.28

Formula

C22H27Cl4N3O2
CAS 号
性状

油状物

颜色

Yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (197.13 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9713 mL 9.8565 mL 19.7130 mL
5 mM 0.3943 mL 1.9713 mL 3.9426 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥95.0%

COA (284 KB) HNMR (141 KB)

产品使用指南 (1538 KB)
参考文献

Amustaline dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9713 mL 9.8565 mL 19.7130 mL 49.2824 mL
5 mM 0.3943 mL 1.9713 mL 3.9426 mL 9.8565 mL
10 mM 0.1971 mL 0.9856 mL 1.9713 mL 4.9282 mL
15 mM 0.1314 mL 0.6571 mL 1.3142 mL 3.2855 mL
20 mM 0.0986 mL 0.4928 mL 0.9856 mL 2.4641 mL
25 mM 0.0789 mL 0.3943 mL 0.7885 mL 1.9713 mL
30 mM 0.0657 mL 0.3285 mL 0.6571 mL 1.6427 mL
40 mM 0.0493 mL 0.2464 mL 0.4928 mL 1.2321 mL
50 mM 0.0394 mL 0.1971 mL 0.3943 mL 0.9856 mL
60 mM 0.0329 mL 0.1643 mL 0.3285 mL 0.8214 mL
80 mM 0.0246 mL 0.1232 mL 0.2464 mL 0.6160 mL
100 mM 0.0197 mL 0.0986 mL 0.1971 mL 0.4928 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amustaline210584-54-6S-303S303S 303HIVBacterialHuman immunodeficiency virusnucleicacidpathogeninactivationredbloodRBCacridineanchoreffectorlinkerInhibitorinhibitorinhibit

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