2. Membrane Transporter/Ion Channel
  3. Chloride Channel
  4. ANO1-IN-1

ANO1-IN-1 (Compound 9c) 是一种选择性的 ANO1 通道阻断剂，对 ANO1 和 ANO2 的 IC50 值分别为 2.56 μM 和 15.43 μM。ANO1-IN-1 强烈抑制胶质瘤细胞的增殖。

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ANO1-IN-1 Chemical Structure

ANO1-IN-1 Chemical Structure

CAS No. : 407587-01-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥370
In-stock
1 mg ￥231
询价
5 mg ￥500
In-stock
10 mg ￥700
In-stock
25 mg ￥1450
In-stock
50 mg ￥2300
In-stock
100 mg ￥3563
In-stock
500 mg 现货 询价
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Customer Review

ANO1-IN-1 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells[1].

IC50 & Target

IC50: 2.56 μM (ANO1), 15.43 μM (ANO2)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Astrocyte GI50
94.83 μM
Compound: 9c
Antiproliferative activity against mouse primary astrocytes assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent assay
Antiproliferative activity against mouse primary astrocytes assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent assay
[PMID: 32906067]
U138-MG GI50
22.24 μM
Compound: 9c
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
12.58 μM
Compound: 9c
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
5.32 μM
Compound: 9c
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-87MG ATCC GI50
31.49 μM
Compound: 9c
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
体外研究
(In Vitro)

ANO1-IN-1 (Compound 9c) (10 μM) significantly suppresses migration and invasion of U251 cells[1].
ANO1-IN-1 and TMZ combination brings about remarkable synergistic effects in suppressing proliferation of GBM cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ANO1-IN-1 相关抗体:
分子量

336.49

Formula

C18H28N2O2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (742.96 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9719 mL 14.8593 mL 29.7186 mL
5 mM 0.5944 mL 2.9719 mL 5.9437 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.57%

COA (194 KB) HNMR (283 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献

ANO1-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9719 mL 14.8593 mL 29.7186 mL 74.2964 mL
5 mM 0.5944 mL 2.9719 mL 5.9437 mL 14.8593 mL
10 mM 0.2972 mL 1.4859 mL 2.9719 mL 7.4296 mL
15 mM 0.1981 mL 0.9906 mL 1.9812 mL 4.9531 mL
20 mM 0.1486 mL 0.7430 mL 1.4859 mL 3.7148 mL
25 mM 0.1189 mL 0.5944 mL 1.1887 mL 2.9719 mL
30 mM 0.0991 mL 0.4953 mL 0.9906 mL 2.4765 mL
40 mM 0.0743 mL 0.3715 mL 0.7430 mL 1.8574 mL
50 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.4859 mL
60 mM 0.0495 mL 0.2477 mL 0.4953 mL 1.2383 mL
80 mM 0.0371 mL 0.1857 mL 0.3715 mL 0.9287 mL
100 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.7430 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANO1-IN-1407587-01-3Chloride ChannelCl− ChannelsANO1 chloride ion channelglioblastomaGBMU87MGU251U138Inhibitorinhibitorinhibit

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