2. Apoptosis Immunology/Inflammation
  3. Pyroptosis NOD-like Receptor (NLR)
  4. Antcin A

Antcin A 是一种 NLRP3 抑制剂，能抑制 NLRP3 炎症小体的组装和激活。Antcin A 能抑制 Kupffer 细胞焦亡 (pyroptosis)，具有肝脏保护活性。Antcin A 可用于炎症的研究，如非酒精性脂肪肝病 (NAFLD)。

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Antcin A Chemical Structure

Antcin A Chemical Structure

CAS No. : 163597-24-8

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规格 价格 是否有货 数量
1 mg ￥2210
1 - 2 周
5 mg   询价  
10 mg   询价  

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Antcin A 相关抗体

Top Publications Citing Use of Products

查看 NOD-like Receptor (NLR) 亚型特异性产品:

查看所有亚型
NLRP3 NLRP1 NOD1 NOD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1].

IC50 & Target

NLRP3[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
39.4 μM
Compound: 17
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 24387703]
BV-2 IC50
4.1 μM
Compound: 15
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
[PMID: 21028898]
Daoy ED50
13.2 μg/mL
Compound: 30
Cytotoxicity against human DaOY cells after 3 days by MTT assay
Cytotoxicity against human DaOY cells after 3 days by MTT assay
[PMID: 21115251]
HeLa ED50
> 20 μg/mL
Compound: 30
Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
[PMID: 21115251]
HEp-2 ED50
> 20 μg/mL
Compound: 30
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
[PMID: 21115251]
KB EC50
4.9 μM
Compound: 15
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
[PMID: 21028898]
MCF7 ED50
13.3 μg/mL
Compound: 30
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
[PMID: 21115251]
MDA-MB-231 IC50
29.6 μM
Compound: 17
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 24387703]
分子量

454.64

Formula

C29H42O4
CAS 号
结构分类
初始来源

Antrodia cinnamomea
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antcin A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antcin A163597-24-8PyroptosisNOD-like Receptor (NLR)inflammasomeinflammationNAFLDKupfferpyroptosisInhibitorinhibitorinhibit

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目录号：
HY-N9921
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