2. NF-κB Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related NF-κB NO Synthase
  4. Anti-inflammatory agent 55

Anti-inflammatory agent 55 (compound 9j) 是薏苡醇 (Coixol) 的衍生物，具有抗炎活性。Anti-inflammatory agent 54 抑制 NF-κB 通路，下调 iNOS、TNF-α、IL-6 和 IL-1β 的表达。Anti-inflammatory agent 54 可抑制 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮 (NO) 产生 (IC50: 0.8 μM)，在小鼠耳廓水肿模型中发挥体内抗炎活性。

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Anti-inflammatory agent 55 Chemical Structure

Anti-inflammatory agent 55 Chemical Structure

CAS No. : 2924156-51-2

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Anti-inflammatory agent 55 相关抗体

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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  • 生物活性

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  • 参考文献

生物活性

Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].

分子量

373.32

Formula

C17H15N3O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 55 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 552924156-51-2TNF ReceptorInterleukin RelatedNF-κBNO SynthaseTumor Necrosis Factor ReceptorTNFRILNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSAnti-inflammatory activityiNOSTNF-αIL-6IL-1βRAW264.7 macrophagesmouse auricle edema modelInhibitorinhibitorinhibit

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