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  4. Anti-inflammatory agent 86

Anti-inflammatory agent 86 是一种具有抗炎作用的 Chrysin (HY-14589) 衍生物。Anti-inflammatory agent 86 抑制 TNF-α 诱导的单核细胞粘附到结肠上皮，IC50 为 4.71 μM。Anti-inflammatory agent 86 具有用于炎症性肠病（IBD）研究的潜力。

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Anti-inflammatory agent 86 Chemical Structure

Anti-inflammatory agent 86 Chemical Structure

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Anti-inflammatory agent 86 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research[1].

体外研究
(In Vitro)

Anti-inflammatory agent 86（化合物 4b）对 TNF-α 诱导的单核细胞粘附 HT-29 细胞表现出显著的抑制活性，IC50 值为 4.71 μM[1]。
Anti-inflammatory agent 86（5-10 μM；4小时）以浓度依赖性方式显着抑制 MCP-1 的表达。Anti-inflammatory agent 86 以剂量依赖性方式抑制 HT-29 细胞中的 NF-κB 活性[1]。
Anti-inflammatory agent 86（5-10 μM）对 TNF-α 诱导的 ROS 生成具有显著的抑制作用，且呈剂量依赖性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 86 相关抗体:

Western Blot Analysis[1]

Cell Line: TNF-α-stimulated HT-29 cells
Concentration: 5 μM, 10 μM
Incubation Time: Pretreatment with 1 h and then treat for 3 hours
Result: Effectively suppressed TNF-α-induced intercellular adhesion molecule (ICAM)-1 expression in a manner.
体内研究
(In Vivo)

Anti-inflammatory agent 86（30-60 mg/kg；口服；每日一次；连续 15 天）在治疗 TNBS 诱导的结肠炎方面表现出最显著的疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley (SD) rats bearing colitis (induced by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS))[1].
Dosage: 30 mg/kg/day or 60 mg/kg/day (10% DMSO, 15% SBE-β-CD, and 75% saline)
Administration: po; once daily; for 15 days
Result: Exhibiteds a dose-dependent inhibition of 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.
分子量

554.72

Formula

C29H34N2O5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 86 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 86OthersChrysinanti-inflammatory effectsTNF-αinflammatory bowel disease (IBD)Inhibitorinhibitorinhibit

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产品名称：
Anti-inflammatory agent 86
目录号：
HY-161757
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