Chrysin (Synonyms: 白杨素; 5,7-Dihydroxyflavone)

目录号: HY-14589 纯度: 99.85%: FAQs
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摩尔计算器

Chrysin 是一种雌激素阻断剂。

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Chrysin Chemical Structure

CAS No. : 480-40-0

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥500	In-stock
500 mg	￥400	In-stock
1 g	￥500	In-stock
5 g		询价
10 g		询价

or 大包装询价

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Customer Review

Other Forms of Chrysin:

Chrysin (Standard) 询价

MCE 顾客使用本产品发表的 7 篇科研文献

Chrysin 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Chrysin is one of the most well known estrogen blockers.

IC₅₀ & Target

estrogen

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
2008	IC₅₀	28.62 μM Compound: 2, Chry	Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
A-375	IC₅₀	29.65 μM Compound: 8	Cytotoxicity against human A375 cells by MTT assay Cytotoxicity against human A375 cells by MTT assay	[PMID: 19782567]
A-375	IC₅₀	33.23 μM Compound: 2, Chry	Cytotoxicity against human A375 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A375 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
A-431	IC₅₀	29.39 μM Compound: 2, Chry	Cytotoxicity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
A-431	IC₅₀	60.13 μM Compound: 2, Chry	Cytotoxicity against cisplatin-resistant human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against cisplatin-resistant human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
A549	IC₅₀	> 1 x 10^-4 M Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by XTT assay Cytotoxicity against human A549 cells after 72 hrs by XTT assay	[PMID: 20619940]
A549	IC₅₀	> 50 μM Compound: 1	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 32160978]
A549	IC₅₀	> 50 μM Compound: Chrysin	Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 31615696]
A549	IC₅₀	19.88 μM Compound: 8	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 19782567]
A549	EC₅₀	233 μM Compound: 3	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 12027739]
A549	IC₅₀	28 μM Compound: Chrysin	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 34171512]
A549	IC₅₀	47.8 μM Compound: Chrysin	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30031652]
B16-BL6	EC₅₀	74.4 μM Compound: 3	Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay	[PMID: 12027739]
B16-F10	IC₅₀	17.45 μM Compound: Chrysin	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 30031652]
BALB/3T3	IC₅₀	248.2 μM Compound: 2	Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay	[PMID: 10096863]
BXPC-3	IC₅₀	54.27 μM Compound: 2, Chry	Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
C13	IC₅₀	49.66 μM Compound: 2, Chry	Cytotoxicity against human C13 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human C13 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
C8166	CC₅₀	110 μg/mL Compound: 5	Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 24794743]
C8166	EC₅₀	13.4 μg/mL Compound: 5	Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis	[PMID: 24794743]
Caco-2	IC₅₀	9.5 μM Compound: 23	Cytotoxicity in human Caco2 cells after 72 hrs by MTT assay Cytotoxicity in human Caco2 cells after 72 hrs by MTT assay	[PMID: 28793973]
DLD-1	IC₅₀	18.62 μM Compound: 4	Antiproliferative activity against human DLD1 cells after 48 hrs by MTT assay Antiproliferative activity against human DLD1 cells after 48 hrs by MTT assay	10.1039/C5MD00163C
DU-145	IC₅₀	9.81 μM Compound: Chrysin	Cytotoxicity against Homo sapiens (human) DU145 cells by MTT assay Cytotoxicity against Homo sapiens (human) DU145 cells by MTT assay	10.1007/s00044-010-9395-1
H22	IC₅₀	1671 μM Compound: 1, Chrysin	Cytotoxicity against mouse H22 cells assessed as growth inhibition by MTT assay Cytotoxicity against mouse H22 cells assessed as growth inhibition by MTT assay	[PMID: 24556144]
H9	IC₅₀	47 μM Compound: 11	Cytotoxicity against human H9 cells after 3 days Cytotoxicity against human H9 cells after 3 days	[PMID: 8158164]
H9	EC₅₀	5 μM Compound: 11	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay	[PMID: 8158164]
HCT-116	IC₅₀	> 100 μM Compound: Chrysin	Cytotoxicity against Homo sapiens (human) HCT116 cells by MTT assay Cytotoxicity against Homo sapiens (human) HCT116 cells by MTT assay	10.1007/s00044-010-9395-1
HCT-15	IC₅₀	54.43 μM Compound: 2, Chry	Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
HEK293	IC₅₀	77.45 μM Compound: 2, Chry	Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
HEK-293T	IC₅₀	319.36 μM Compound: Chrysin	Cytotoxicity against human 293T cells after 48 hrs by MTT assay Cytotoxicity against human 293T cells after 48 hrs by MTT assay	[PMID: 30031652]
HeLa	IC₅₀	≥ 10 μM Compound: chrysin	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 19278239]
HeLa	EC₅₀	111 μM Compound: 3	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 12027739]
HeLa	IC₅₀	14.2 μM Compound: Chrysin	Cytotoxicity in human HeLa cells assessed as reduction in cell viability incubated for 24 to 72 hrs by MTT assay Cytotoxicity in human HeLa cells assessed as reduction in cell viability incubated for 24 to 72 hrs by MTT assay	[PMID: 28797675]
HeLa	IC₅₀	2.9 x 10^-5 M Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by XTT assay Cytotoxicity against human HeLa cells after 72 hrs by XTT assay	[PMID: 20619940]
HeLa	IC₅₀	25.05 μM Compound: Chrysin	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30031652]
HeLa	IC₅₀	43 μM Compound: Chrysin	Cytotoxicity against Homo sapiens (human) HeLa cells by MTT assay Cytotoxicity against Homo sapiens (human) HeLa cells by MTT assay	10.1007/s00044-010-9395-1
HepG2	IC₅₀	> 100 μM Compound: Chrysin	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 26896708]
HepG2	IC₅₀	16.5 μM Compound: 4	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	10.1039/C5MD00163C
HL-60	IC₅₀	33.98 μM Compound: 8	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 19782567]
HT-1080	EC₅₀	94.9 μM Compound: 3	Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 12027739]
HT-29	IC₅₀	> 1 x 10^-4 M Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay	[PMID: 20619940]
HT-29	IC₅₀	19.49 μM Compound: 4	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	10.1039/C5MD00163C
Huh-7	CC₅₀	> 50 μM Compound: 18	Cytotoxicity against human Huh7.5.1 cells by MTT assay Cytotoxicity against human Huh7.5.1 cells by MTT assay	[PMID: 22445328]
Jurkat	IC₅₀	4.9 μM Compound: Chrysin	Inhibition of chymotrypsin-like activity of purified human 20S proteasome expressed in human Jurkat cells assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 2 hrs by fluorescence based method Inhibition of chymotrypsin-like activity of purified human 20S proteasome expressed in human Jurkat cells assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 2 hrs by fluorescence based method	[PMID: 30776692]
Jurkat	IC₅₀	6.1 μM Compound: Chrysin	Inhibition of chymotrypsin-like activity of human 26S proteasome in human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly-Gly-Leu-AMC as substrate after 24 hrs by fluorescence based method Inhibition of chymotrypsin-like activity of human 26S proteasome in human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly-Gly-Leu-AMC as substrate after 24 hrs by fluorescence based method	[PMID: 30776692]
K562	IC₅₀	> 100 μM Compound: Chrysin	Cytotoxicity against Homo sapiens (human) K562 cells by MTT assay Cytotoxicity against Homo sapiens (human) K562 cells by MTT assay	10.1007/s00044-010-9395-1
K562	IC₅₀	> 50 μM Compound: 1	Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 32160978]
K562	IC₅₀	> 50 μM Compound: Chrysin	Antiproliferative activity against human K562 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 31615696]
KB	IC₅₀	29.6 μM Compound: Chrysin	Antiproliferative activity against human KB cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human KB cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 34171512]
KYSE-510	IC₅₀	63 μM Compound: Chrysin	Cytotoxicity in human KYSE-510 cells assessed as reduction in cell viability incubated for 24 to 72 hrs by MTT assay Cytotoxicity in human KYSE-510 cells assessed as reduction in cell viability incubated for 24 to 72 hrs by MTT assay	[PMID: 28797675]
L02	IC₅₀	> 100 μM Compound: Chrysin	Cytotoxicity against human LO2 cells after 48 hrs by MTT assay Cytotoxicity against human LO2 cells after 48 hrs by MTT assay	[PMID: 26896708]
MCF7	IC₅₀	2.6 μM Compound: 10	Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining	[PMID: 21354800]
MCF7	IC₅₀	25.66 μM Compound: Chrysin	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30031652]
MCF7	IC₅₀	26.9 μM Compound: Chrysin	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 34171512]
MCF7	IC₅₀	50 nM Compound: Chrysin	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay	[PMID: 33257172]
MCF7	IC₅₀	50.32 μM Compound: 2, Chry	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
MCF7	GI₅₀	69 μM Compound: Chrysin	Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by SRB assay Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by SRB assay	10.1007/s00044-012-0423-1
MDA-MB-231	IC₅₀	33 μM Compound: Chrysin	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 34171512]
MDCK	IC₅₀	1.5 μM Compound: 10	Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining	[PMID: 21354800]
Mesenchymal stem cells	EC₅₀	77.7 μM Compound: 1	Induction of adiponectin secretion in human BMMSC cells in presence of IDX induction medium by ELISA assay Induction of adiponectin secretion in human BMMSC cells in presence of IDX induction medium by ELISA assay	[PMID: 37077388]
MOLT-4	GI₅₀	58.6 μM Compound: Chrysin	Cytotoxicity against Homo sapiens (human) MOLT4 cells after 48 hr by SRB assay Cytotoxicity against Homo sapiens (human) MOLT4 cells after 48 hr by SRB assay	10.1007/s00044-012-0423-1
Monocyte	IC₅₀	2.4 μM Compound: chrysin	Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs	[PMID: 8882428]
MRC5	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human MRC5 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 32160978]
MRC5	IC₅₀	> 100 μM Compound: Chrysin	Cytotoxicity against human MRC5 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 31615696]
NCI/ADR-RES	IC₅₀	51.04 μM Compound: 2, Chry	Cytotoxicity against human MCF7/ADR cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7/ADR cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
NCI-H1299	IC₅₀	> 50 μM Compound: 1	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 32160978]
NCI-H1299	IC₅₀	> 50 μM Compound: Chrysin	Antiproliferative activity against human H1299 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human H1299 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 31615696]
Neutrophil	IC₅₀	53 μM Compound: 4a	Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of ROS-induced luminol oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of ROS-induced luminol oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay	[PMID: 23871908]
Neutrophil	IC₅₀	9.59 μM Compound: 4a	Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay	[PMID: 23871908]
PC-3	IC₅₀	> 50 μM Compound: 1	Antiproliferative activity against human PC3 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 32160978]
PC-3	IC₅₀	> 50 μM Compound: Chrysin	Antiproliferative activity against human PC3 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 31615696]
RBL-2H3	IC₅₀	> 500 μM Compound: 11	Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge	[PMID: 14510616]
RD	EC₅₀	15.89 μM Compound: CR	Antiviral activity against EV71 infected in human RD cells assessed as protection against virus infection after 72 hrs by MTS assay Antiviral activity against EV71 infected in human RD cells assessed as protection against virus infection after 72 hrs by MTS assay	[PMID: 27776325]
SGC-7901	IC₅₀	> 100 μM Compound: Chrysin	Cytotoxicity against Homo sapiens (human) SGC7901 cells by MTT assay Cytotoxicity against Homo sapiens (human) SGC7901 cells by MTT assay	10.1007/s00044-010-9395-1
SW480	IC₅₀	31.08 μM Compound: 4	Antiproliferative activity against human SW480 cells after 48 hrs by MTT assay Antiproliferative activity against human SW480 cells after 48 hrs by MTT assay	10.1039/C5MD00163C
T-cell	CC₅₀	428.27 μM Compound: 1, CR	Cytotoxicity against BALB/c mouse T cells after 48 hrs by MTT assay Cytotoxicity against BALB/c mouse T cells after 48 hrs by MTT assay	[PMID: 21131104]
T-cell	IC₅₀	44.16 μM Compound: 1, CR	Immunosuppressive activity in BALB/c mouse T cells assessed as inhibition of anti-CD3/anti-CD28-stimulated cell proliferation after 72 hrs by MTT assay Immunosuppressive activity in BALB/c mouse T cells assessed as inhibition of anti-CD3/anti-CD28-stimulated cell proliferation after 72 hrs by MTT assay	[PMID: 21131104]
THP-1	IC₅₀	23.38 μM Compound: 8	Cytotoxicity against human THP1 cells by MTT assay Cytotoxicity against human THP1 cells by MTT assay	[PMID: 19782567]

体外研究
(In Vitro)

Chrysin 主要存在于西番莲、蜂蜜和蜂胶中，是一种潜在的治疗和预防剂，可抑制多种人类癌细胞的增殖和侵袭。尽管 Chrysin 在多种癌症中具有抗癌作用，但对其在卵巢癌中的功能作用知之甚少，而卵巢癌的预后较差且对传统治疗药物具有化疗耐药性。Chrysin 通过增加活性氧 (ROS) 产生和细胞质 Ca²⁺ 水平以及诱导线粒体膜电位 (MMP) 损失来抑制卵巢癌细胞增殖并诱导细胞死亡。在浓度反应实验中，Chrysin 激活 ES2 和 OV90 细胞中的 MAPK 和 PI3K/AKT 通路。Chrysin 通过调节经典 Wnt 和核因子 NF-κB 信号通路级联癌细胞来抑制肿瘤生长。与未处理的对照细胞相比，Chrysin 刺激 ES2 和 OV90 细胞中 AKT 和 P70S6K 蛋白的磷酸化。此外，Chrysin 还可激活卵巢癌细胞中 MAPK 通路成员的磷酸化 ERK1/2、p38 和 JNK 蛋白^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

254.24

Formula

C₁₅H₁₀O₄

CAS 号

480-40-0

性状

固体

颜色

Light yellow to yellow

中文名称

柯因；5,7-二羟黄酮

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 100 mg/mL (393.33 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9333 mL	19.6665 mL	39.3329 mL
5 mM	0.7867 mL	3.9333 mL	7.8666 mL
10 mM	0.3933 mL	1.9666 mL	3.9333 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.83 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.83 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： 50% PEG300 50% Saline
Solubility: 10 mg/mL (39.33 mM); 悬浊液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.85%

选择批次：

Data Sheet (645 KB) SDS (393 KB)

COA (193 KB) HNMR (267 KB) LCMS (93 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Lim W, et al. Chrysin Attenuates Progression of Ovarian Cancer Cells by Regulating Signaling Cascades and Mitochondrial Dysfunction. J Cell Physiol. 2017 Aug 17. [Content Brief]

Cell Assay ^[1]	The proliferation assays are conducted using a cell proliferation enzyme-linked immunosorbent assay (ELISA) 5-bromo-2'-deoxyuridine (BrdU) kit. Briefly, ES2 and OV90 cells are seeded in a 96-well plate, and then treated with Chrysin (0, 5, 10, 20, 50, and 100 µM) with or without inhibitors (20 μM LY294002, PI3K/AKT; 10 μM U0126, ERK1/2; 10 μM SP600125, JNK; and 20 μM SB203580, p38) in a final volume of 100 μL/well. Aftera48-h incubation, 10 μM BrdU is added to the cell culture, followed by an additional 2-h incubation at 37°C. After labeling the cells with BrdU, they are fixed and then incubated with the anti-BrdU-peroxidase (POD) working solution for 90 min. The anti-BrdU-POD binds to the BrdU incorporated into newly synthesized cellular DNA and these immune complexes are detected by analyzing their reaction with the 3,3',5,5'-tetramethylbenzidine (TMB) substrate. The absorbance values of the reaction product are measured at 370 and 492 nm using an ELISA reader^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Lim W, et al. Chrysin Attenuates Progression of Ovarian Cancer Cells by Regulating Signaling Cascades and Mitochondrial Dysfunction. J Cell Physiol. 2017 Aug 17. [Content Brief]

Cell Assay
^[1]

The proliferation assays are conducted using a cell proliferation enzyme-linked immunosorbent assay (ELISA) 5-bromo-2'-deoxyuridine (BrdU) kit. Briefly, ES2 and OV90 cells are seeded in a 96-well plate, and then treated with Chrysin (0, 5, 10, 20, 50, and 100 µM) with or without inhibitors (20 μM LY294002, PI3K/AKT; 10 μM U0126, ERK1/2; 10 μM SP600125, JNK; and 20 μM SB203580, p38) in a final volume of 100 μL/well. Aftera48-h incubation, 10 μM BrdU is added to the cell culture, followed by an additional 2-h incubation at 37°C. After labeling the cells with BrdU, they are fixed and then incubated with the anti-BrdU-peroxidase (POD) working solution for 90 min. The anti-BrdU-POD binds to the BrdU incorporated into newly synthesized cellular DNA and these immune complexes are detected by analyzing their reaction with the 3,3',5,5'-tetramethylbenzidine (TMB) substrate. The absorbance values of the reaction product are measured at 370 and 492 nm using an ELISA reader^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Lim W, et al. Chrysin Attenuates Progression of Ovarian Cancer Cells by Regulating Signaling Cascades and Mitochondrial Dysfunction. J Cell Physiol. 2017 Aug 17. [Content Brief]

Chrysin 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9333 mL	19.6665 mL	39.3329 mL	98.3323 mL
	5 mM	0.7867 mL	3.9333 mL	7.8666 mL	19.6665 mL
	10 mM	0.3933 mL	1.9666 mL	3.9333 mL	9.8332 mL
	15 mM	0.2622 mL	1.3111 mL	2.6222 mL	6.5555 mL
	20 mM	0.1967 mL	0.9833 mL	1.9666 mL	4.9166 mL
	25 mM	0.1573 mL	0.7867 mL	1.5733 mL	3.9333 mL
	30 mM	0.1311 mL	0.6555 mL	1.3111 mL	3.2777 mL
	40 mM	0.0983 mL	0.4917 mL	0.9833 mL	2.4583 mL
	50 mM	0.0787 mL	0.3933 mL	0.7867 mL	1.9666 mL
	60 mM	0.0656 mL	0.3278 mL	0.6555 mL	1.6389 mL
	80 mM	0.0492 mL	0.2458 mL	0.4917 mL	1.2292 mL
	100 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.9833 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chrysin480-40-05,7-Dihydroxyflavone柯因5,7-二羟黄酮Estrogen Receptor/ERRInhibitorinhibitorinhibit

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Chrysin (Synonyms: 白杨素; 5,7-Dihydroxyflavone)

Customer Review

Other Forms of Chrysin:

MCE 顾客使用本产品发表的 7 篇科研文献

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参考文献

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完整储备液配制表

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Chrysin (Synonyms: 白杨素; 5,7-Dihydroxyflavone)

Customer Review

Other Forms of Chrysin:

Chrysin 相关抗体

MCE 顾客使用本产品发表的 7 篇科研文献

Chrysin 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 Estrogen Receptor/ERR 亚型特异性产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Chrysin 相关抗体:

摩尔计算器

稀释计算器

Chrysin 相关分类

完整储备液配制表

Keywords:

您最近查看的产品:

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