Antibiotic A-33853  (Synonyms: 化合物 T26416)

Antibiotic A-338533, an antibiotic, can be isolated from Streptomyces strain. Antibiotic A-338533 has anti-bacterial activity against Staphylococcus aureus, Mycoplasma gallisepticum with MIC values of 2 μg/mL and ≤1.56 μg/mL, respectively^[1].

Antibiotic A-33853 对球虫病的主要致病菌嫩艾美耳菌 (Eimeria tenella) 有抑制作用，对阴道毛滴虫 (Trichomonas vaginalis) 的 MIC<0.975 μg/mL^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibiotic A-33853 (60 mg/kg；皮下注射；单次剂量) 对雏鸡体内的鸡毒支原体无效^[1]。
Antibiotic A-33853 (70 mg/kg；皮下注射；两次剂量) 对小鼠体内的金黄色葡萄球菌无效^[1]。
Antibiotic A-33853 对小鼠模型的急性毒性剂量的 LD₅₀ 值为 300 mg/kg (腹腔注射)^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

391.33

C₂₀H₁₃N₃O₆

80148-45-4

化合物 T26416

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. In Pursuit of Natural Product Leads: Synthesis and Biological Evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and Its Analogues: Discovery of N-(2-Benzoxazol-2-ylphenyl)benzamides as Novel Antileishmanial Chemotypes J. Med. Chem., 2008, 51 (23), pp 7344-7347

  [2]. Michel KH, et al. The discovery, fermentation, isolation, and structure of antibiotic A33853 and its tetraacetyl derivative. J Antibiot (Tokyo). 1984 May;37(5):441-5.  [Content Brief]