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  4. Antimalarial agent 11

Antimalarial agent 11 (compound 1) 是一种螺环色烷，一种有效的抗疟 (antimalarial) 剂。Antimalarial agent 11 表现出优异的抗氯喹 Dd2 菌株的效力，EC50 为 350 nM。Antimalarial agent 11 对 D6 和 ARC08-022 的 EC50 分别为 1.48 µM 和 1.81 µM。

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Antimalarial agent 11 Chemical Structure

Antimalarial agent 11 Chemical Structure

CAS No. : 1214454-56-4

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Antimalarial agent 11 相关抗体

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生物活性

Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
> 20 μM
Compound: 1
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 35091169]
HepG2 EC50
19 μM
Compound: 82
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 35461019]
HepG2 EC50
19 μM
Compound: 64
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 33069128]
分子量

425.47

Formula

C25H25F2NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antimalarial agent 11 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 111214454-56-4Antimalarial agent11Antimalarial agent-11Parasitespirocyclic chromaneantimalarialChloroquineDd2 strainD6ARC08-022Inhibitorinhibitorinhibit

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