2. Anti-infection
  3. Parasite
  4. Antimalarial agent 38

Antimalarial agent 38 (Compound 1) 是一种抗疟原虫剂，抑制恶性疟原虫 Plasmodium falciparum D6 株，氯喹敏感的Thai 株和氯喹耐受的 FcB1 株和 K1 株，IC50 分别为 0.5，13，1 和 13 μM。Antimalarial agent 38 对哺乳动物细胞 MCR58 不具备细胞毒性 (IC50 >140 μM)。Antimalarial agent 38 提高了 Plasmodium yoelii nigeriensis 感染小鼠的存活率。

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Antimalarial agent 38 Chemical Structure

Antimalarial agent 38 Chemical Structure

CAS No. : 123580-46-1

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Antimalarial agent 38 相关抗体

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生物活性

Antimalarial agent 38 (Compound 1) exhibits activity against antiplasmodial, which inhibits Plasmodium falciparum D6 strain, chloroquine-sensitive Thai strain and chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model[1].

分子量

692.71

Formula

C36H40N2O12
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Antimalarial agent 38 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 38123580-46-1Antimalarial agent38Antimalarial agent-38ParasiteMCR58P. falciparumN67swiss mousePlasmodium yoelii nigeriensisInhibitorinhibitorinhibit

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