2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway JAK/STAT Signaling
  3. Src VEGFR Raf EGFR
  4. Antiproliferative agent-54

Antiproliferative agent-54 (Compound 6z) 是多种激酶的抑制剂，例如 ABL WT、B-RAF、EGFR、HCK、LYN A 和 SRC，IC50 为 6-50 nM。Antiproliferative agent-54 抑制多种癌细胞的增殖，对 HUVEC 和 HepG2 的 EC50 分别为 34 和 38 nM。Antiproliferative agent-54 在大鼠体内表现出良好的药代动力学特征。

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Antiproliferative agent-54 Chemical Structure

Antiproliferative agent-54 Chemical Structure

CAS No. : 1240322-54-6

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Antiproliferative agent-54 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

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Lck Fyn Blk

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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BRaf c-Raf Raf

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-54 (Compound 6z) is the inhibitor for multiple kinases, such as ABL WT, B-RAF, EGFR, HCK, LYN A and SRC with IC50 of 6-50 nM. Antiproliferative agent-54 inhibits proliferation of several cancer cell, inhibits HUVEC and HepG2, with EC50 of 34 and 38 nM. Antiproliferative agent-54 exhibits good pharmacokinetic characteristics in rats[1].

IC50 & Target

IC50: 6 nM (ABL WT); 10 nM (B-RAFV600E); 15 nM (EGFR WT); 22 nM (HCK); 37 nM (LYN A); 40 nM (c-SRC); 44 nM (YES); 46 nM (ABLG250E); 50 nM (PDGFRA)
分子量

562.54

Formula

C29H25F3N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-54 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-541240322-54-6Antiproliferative agent54Antiproliferative agent 54SrcVEGFRRafEGFRVascular endothelial growth factor receptorRaf kinasesEpidermal growth factor receptorErbB-1HER1HepG2Swiss mouseHUVECInhibitorinhibitorinhibit

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