2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Antipsychotic agent-2

Antipsychotic agent-2 (Compound 11) 是一种有效的抗精神病剂。Antipsychotic agent-2 对 5-HT1A、5-HT2A、5-HT2C、D2 和 H1 受体具有亲和力，Ki 分别为 56.6、66.7、552、596 和 1140 nM。Antipsychotic agent-2 可以透过血脑屏障。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Antipsychotic agent-2 Chemical Structure

Antipsychotic agent-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Antipsychotic agent-2 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antipsychotic agent-2 (Compound 11) is a potent antipsychotic agent. Antipsychotic agent-2 shows affinities for 5-HT1A, 5-HT2A, 5-HT2C, D2 and H1 receptors with Kis of 56.6, 66.7, 552, 596 and 1140 nM, respectively. Antipsychotic agent-2 has BBB permeability[1].

IC50 & Target

5-HT1A Receptor

160 nM (EC50)

5-HT2A Receptor

96.4 nM (Kb)

D2 Receptor

45.7 nM (Kb)

体外研究
(In Vitro)

Antipsychotic agent-2 (Compound 11) 拮抗 10-6 M 多巴胺在稳定表达人 D2 受体的 CHO-K1 细胞中抑制 Forskolin (HY-15371) 刺激的 cAMP 产生，这表明了对 D2 的拮抗作用 (Kb=45.7 nM)[1]。
Antipsychotic agent-2 在浓度依赖的方式下抑制在稳定表达 5-HT1A 受体的 HEK293 细胞中由 Forskolin 刺激的 cAMP 产生，这表明了对 5-HT1A 的激动剂活性 (EC50=160 nM)，而它表现为 5-HT2A 拮抗剂，对抗 10-6 M 5-HT 在表达 5-HT2A 受体的 CHO-K1 细胞中刺激的肌醇磷酸产生 (Kb=96.4 nM)[1]。
Antipsychotic agent-2 (0.1-10 μM) 是一种相对低效的 CYP3A4 诱导剂[1]。
Antipsychotic agent-2 (0.3-30 μM; 72 h) 表现出良好的安全性，并且只在 30 μM 的浓度下显示出对 SH-SY5Y 显著的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antipsychotic agent-2 相关抗体:
体内研究
(In Vivo)

Antipsychotic agent-2 (Compound 11; 20-80 mg/kg; i.p.; once) 诱导小鼠自发运动活动发生统计学显著变化[1]。
Antipsychotic agent-2 (40 mg/kg; i.p.; once) 降低安非他明 (amphetamine) 引起的小鼠多动症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naive Swiss male mice, amphetamine-induced hyperactivity[1]
Dosage: 40 mg/kg
Administration: IP, once
Result: Decreased amphetamine-induced hyperactivity.
分子量

395.47

Formula

C22H26FN5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antipsychotic agent-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antipsychotic agent-2Antipsychotic agent2Antipsychotic agent 25-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorCHO-K1CYP3A4ForskolincAMPHEK293spontaneous locomotor activityInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Antipsychotic agent-2
目录号：
HY-149247
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z