2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Antitumor agent-88

Antitumor agent-88 表现出有效的抗有丝分裂活性并使细胞停滞在 G2/M 期。Antitumor agent-88 扰乱表达 CYP1A1 的乳腺癌细胞中的微管和细胞骨架。Antitumor agent-88 也是 CYP1A1 的竞争性抑制剂 (Ki: 1.4 μM)。

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Antitumor agent-88 Chemical Structure

Antitumor agent-88 Chemical Structure

CAS No. : 1422527-87-4

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Antitumor agent-88 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-88 exhibits potent antimitotic activity and arrests cell in the G2/M phase. Antitumor agent-88 disrupts the microtubule and the cytoskeleton in CYP1A1-expressing breast cancer cells. Antitumor agent-88 is also a competitive inhibitor of CYP1A1 (Ki: 1.4 μM)[1].

IC50 & Target[1]

CYP1A1

1.4 μM (Ki)

体外研究
(In Vitro)

Antitumor agent-88 (Compound 14, 48 h) 抑制 MCF-7 细胞生长，IC50 为 200 nM，对 MDA-MB-231 (IC50 >8600 nM)[1]。
Antitumor agent-88 抑制 MDA-MB-468、SK-BR 细胞生长，IC50 分别为 21 nM、3.2 nM[1]。
Antitumor agent-88 (50 nM, 48 h) 导致 42% 细胞在 G2/M 期停滞[1]。
Antitumor agent-88 对 CYP1A1 具有高亲和力 (Ki: 1.4 μM)[1]。
Antitumor agent-88 选择性抑制 HT-1080 细胞增殖，对转染 CYP1A1 的 HT-1080 的 IC50 为 30 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-88 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 cell
Concentration: 50 nM
Incubation Time: 48 h
Result: Arrested cell in G2/M phase.
体内研究
(In Vivo)

Antitumor agent-88 (化合物 14) (1 μg/蛋) 在携带 HT-1080CYP1A1 肿瘤的鸡胚中显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chick embryos grafted with HT-1080CYP1A1 cells[1]
Dosage: 1 μg/egg
Administration: Applied to chick chorioallantoic membrane.
Result: Reduced tumor weight by 49%.
分子量

478.56

Formula

C23H30N2O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-88 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-881422527-87-4Antitumor agent88Antitumor agent 88Cytochrome P450CYPsAnti-tumorMCF-7CYP1A1HT-1080breast cancerMDA-MB-468SK-BRInhibitorinhibitorinhibit

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