2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. AP1153 aptamer sodium

AP1153 aptamer sodium 是特异性结合胆囊收缩素受体 CCKBR 的 DNA 适体 (Kd: ~15 pM)，但不激活 CCKBR 相关信号通路。AP1153 aptamer sodium 以受体介导的方式被胰腺导管腺癌 (PDAC) 细胞内化。AP1153 aptamer sodium 可以与荧光纳米颗粒表面发生生物共轭，在体内促进纳米颗粒递送至 PDAC 肿瘤。

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DNA, 5'-CATGGTGCAGGTGTGGCTGGGATTCATTTGCCGGTGCTGGTGCGTCCGCGGCCGCTAATCCTGTTC-3', sodium salt

AP1153 aptamer sodium Chemical Structure

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AP1153 aptamer sodium 相关抗体

Top Publications Citing Use of Products

查看 Cholecystokinin Receptor 亚型特异性产品:

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CCKAR CCKBR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo[1].

IC50 & Target

Kd: ~15 pM (CCKBR)[1]
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AP1153 aptamer sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP1153 aptamerCholecystokinin ReceptorCCK ReceptorDNA aptamerpancreatic cancertargeted nanoparticlestumor imagingInhibitorinhibitorinhibit

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